Washed Red Blood Cells

Question 1

What is the shelf life of washed red blood cells in an open system?

Answer 1

• The shelf life of washed red blood cells in an open system is 24 hours.

Question 2

What is the status of washed red blood cells in terms of the system they are in?

Answer 2

• Washed red blood cells are in an open system.

Question 3

Why is a closed system not yet fully developed in the context of washed red blood cells?

Answer 3

• A closed system is not yet fully developed because it requires the introduction of a wash solution.

Question 4

How many Celcius in the storage temp for Washed Red Blood Cells

Answer 4

> 1-6ºC ref temp

Question 5

Why is plasma removal necessary in individuals with specific conditions such as febrile reactions, paroxysmal nocturnal hemoglobinuria, patients with antibodies, IgA deficiency, and alloantibodies?

Answer 5

• Plasma removal is required because it contain offending proteins/antibodies that can trigger transfusion-associated reactions
• Including febrile reactions paroxysmal nocturnal hemoglobinuria, and adverse reactions in patients with antibodies, IgA deficiency, and alloantibodies.

Question 6

What is the significance of MAJOR-PT SERUM – DONOR REDCELL in terms of antibodies and antigen reactions?

Answer 6

• It plays a crucial role in identifying antibodies present in a patient’s serum that will react with antigens on donor red blood cells.

Question 7

What has replaced the minor crossmatch in routine pre-transfusion procedures?

Answer 7

• Replaced by antibody screening and donor serum antibody screening as part of routine pre-transfusion procedures.
• It is only performed if specifically requested.

Question 8

Give the Indications in WASHED RED BLOOD CELLS- OPEN SYSTEM

Answer 8

• Anemia with history of febrile reactions; PNH; for pxs with plasma proteins
  antibodies to reduced allergic reactions (for IgA-deficient pxs)
• Became a requirement for alloimmunization patient reaction