13th Page

Question 1

IgA

Answer 1

provides natural passive immunity

predominant in body secretions such as tears, saliva, colostrum, milk, and intestinal fluids.

Question 2

What are the subclasses of IgA?

Answer 2

IgA1, which is a monomer found in serum

IgA2, which is a dimer found in secretions, held together by a J chain.

Question 3

How does IgA protect itself during transport?

Answer 3

IgA binds to a glycoprotein (secretory component)

Question 4

Protects IgA from digestion by proteolytic enzymes and facilitates its transport to mucosal surfaces

Answer 4

Secretory component

Question 5

IgM

Answer 5

largest antibody (megastar)

Question 6

primary response antibody.

Answer 6

IgM

Question 7

What are the forms of IgM?

Answer 7

monomer or a pentamer

Question 8

IgM has how many antigen binding sites that are available for effector functions due to steric hindrances

Answer 8

5-6

Question 9

IgM reacts at what temperature?

Answer 9

COLD

Question 10

first antibody formed by the fetus

Answer 10

IgM

Question 11

IgM

Answer 11

IgM is the first antibody to appear during an immune response and is the last to leave in senescence.

Question 12

IgM

Answer 12

most efficient antibody that activates the complement system.

Question 13

Agglutinating Ig

Answer 13

IgM

Question 14

Cold-reacting Ab

Answer 14

IgM

Question 15

Acute Infection Ig

Answer 15

IgM

Question 16

Has the longest hinge region

Answer 16

IgD

Question 17

IgD

Answer 17

found on the surface of mature and naive B cells in association with IgM.

Question 18

What role does IgD play in B cells?

Answer 18

antigen recognition by B cells and signals B cells for antibody production.

Question 19

Extremely susceptible to proteolysis

Answer 19

IgD

Question 20

Drive B cells to produce antibody for immunoregulation

Answer 20

IgD

Question 21

Antibody for hypersensitivity

Answer 21

IgE

Question 22

Antibody that defense against parasitic worm?

Answer 22

IgE

Question 23

IgE

Answer 23

least abundant immunoglobulin in the serum.

Question 24

IgE

Answer 24

most heat labile antibody

Question 25

Reaginic antibody

Answer 25

IgE

Question 26

IgE

Answer 26

binds strongly to receptors on mast cells and basophils, mediating the release of histamine and heparin.

Question 27

IgE

Answer 27

IgE mediates some types of hypersensitivity reactions, allergies, and anaphylaxis.

Question 28

Generally responsible for immunity to invading pararsites (IL-4)

Answer 28

IgE

Question 29

greatest plasma concentration

Answer 29

IgG

Question 30

body secretions (saliva, tears)

Answer 30

IgA

Question 31

mega (largest)

Answer 31

IgM

Question 32

activates complement easily

Answer 32

IgM

Question 33

pentaMer

Answer 33

IgM

Question 34

Drive B cells

Answer 34

IgD

Question 35

Allergy

Answer 35

IgE

Question 36

Lag phase

Answer 36

No antibody is detectable. ## Footnote This phase is known as the '1a9 phase'.

Question 37

Log phase

Answer 37

The antibody titer increases logarithmically. ## Footnote This indicates a rapid increase in antibody levels.

Question 38

Plateau phase

Answer 38

The antibody titer stabilizes. ## Footnote This phase is characterized by a steady level of antibodies.

Question 39

Decline phase

Answer 39

The antibody is catabolized. ## Footnote This phase marks the decrease in antibody levels.

Question 40

What defines the primary antibody response?

Answer 40

It is the first immune response to the first encounter with a specific immunogen. ## Footnote This includes a longer lag phase and lower antibody titer.

Question 41

Initial challenge of the immune system

Answer 41

Primary antibody

Question 42

Characteristics of the primary antibody response?

Answer 42

1. Predominant antibody produced: IgM 2. Longer lag phase 3. Decrease/low antibody titer

Question 43

Secondary (anamnestic) antibody response?

Answer 43

It is the immune response to subsequent exposure to the same antigenic stimulus. ## Footnote This response is faster and stronger.

Question 44

Characteristics of the secondary antibody response?

Answer 44

1. Predominant antibody produced: IgG 2. Shorter lag phase 3. Longer stationary/plateau phase 4. More gradual decline phase 5. Increase in antibody titer 6. Faster and stronger response

Question 45

Most abundant Ab in the body

Answer 45

IgA

Question 46

Most abundant Ab in serum

Answer 46

IgG

Question 47

Ratio of IgG to IgA in serum

Answer 47

10:1

Question 48

Least abundant Ab in the serum

Answer 48

IgE

Question 49

Most effective in complement fixation

Answer 49

IgM

Question 50

Longest hinge region

Answer 50

IgD

Question 51

Longest hinge region in IgG classes

Answer 51

IgG3

Question 52

Incomplete or non-agglutinating Ab

Answer 52

IgG

Question 53

Significant Ab type often implicated in HTR and HDN

Answer 53

IgG

Question 54

IgG that cannot cross the placenta

Answer 54

IgG2

Question 55

IgG that is most efficient in complement fixation

Answer 55

IgG3

Question 56

IgG that CANNOT fix complement

Answer 56

IgG4

Question 57

IgGs that have high affinity to Fc receptors of phagocytic cells, increasing efficiency of phagocytosis

Answer 57

IgG1 and IgG3

Question 58

An excellent neutralizing Ab

Answer 58

IgG

Question 59

The only Ab with secretory components

Answer 59

IgA

Question 60

Major Ab found in the colostrum in the mother's milk

Answer 60

IgA

Question 61

Ab most often formed in response to Gram (-) bacteria

Answer 61

IgM

Question 62

Last to leave in senescence

Answer 62

IgM

Question 63

First Ab that is formed by the fetus

Answer 63

IgM

Question 64

First Ab to appear during an immune response

Answer 64

IgM

Question 65

Abs in the membrane of B cells

Answer 65

IgM, IgD

Question 66

Most heat-labile Ab

Answer 66

IgE