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Immunology And Serology BOARD EXAM > 29th Page > Flashcards

29th Page Flashcards

(54 cards)

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1
Q

What are the markers for Hepatitis B?

A

HBsAg, Anti-HBc, Anti-HBs

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2
Q

No exposure/ Candidate for immunization

A

All negative in HBsAg, Anti-HBc, Anti-HBs

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3
Q

Infected early stage

A

HBsAg- pos
Anti-HBc- neg
Anti-HBs-neg

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4
Q

Acute/Chronic

A

HBsAg- pos
Anti-HBc- pos
Anti-HBs- neg

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5
Q

Window phase

A

HBsAg- neg
Anti-HBc- pos
Anti-HBs- neg

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6
Q

Immune bec. of vaccination

A

HBsAg- neg
Anti-HBc- neg
Anti-HBs- pos

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6
Q

Immune bec. of infection

A

HBsAg- neg
Anti-HBc-pos
Anti-HBs- pos

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7
Q

What is the average incubation period for Hepatitis C (HCV)?

A

15-150 days

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8
Q

What percentage of chronic hepatitis occurs in Hepatitis C?

A

40-60%

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9
Q

What is the mortality rate for Hepatitis C?

A

0.5-1.0%

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10
Q

What tests are used to detect current Hepatitis C infection?

A

HCV RNA for confirmation

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11
Q

What does a nonreactive NAT suggest?

A

A past HCV infection or false-positive antibody test result.

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12
Q

monitor effectiveness of therapy and determine HCV genotype

A

HCV RNA Viral Load

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13
Q

family of HCV

A

Flaviviridae

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14
Q

Non-A Non-B Hepatitis

Post-transfusion hepatitis

A

HCV

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15
Q

MOT of HCV

A

Sexual
Parenteral
Perinatal/vertical
Blood transfusion

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16
Q

Hepatitis D (HDV) requires what?

A

HBV for its replication.

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17
Q

What are the markers for Hepatitis D?

A

Anti-HDV IgM
Anti-HDV IgG
HDV RNA
C-infection
super infection
chronic infection

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18
Q

What is the mode of transmission for Hepatitis E (HEV)?

A

Fecal-oral; mostly through contaminated drinking water.

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19
Q

What is the mortality rate of Hepatitis E in pregnant women?

A

20% to 25% due to obstetric complications.

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20
Q

What are the markers for Hepatitis E?

A

IgM Anti-HEV
IgG Anti-HEV
HEV RNA

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21
Q

What is the mode of transmission for Hepatitis G (HGV)?

BT

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A

Blood-borne route
Tansplacental (rarely).

22
Q

Molecular Assays quantitative

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A

performed RT-PCR, real-time PCR, or bDNA ampflication

monitor amount of HCV RNA viral load

23
Q

Molecular Assays qualitative

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A

Detect presence or absence of HCV RNA
Confirm infection HCV Ab-pos
Detect infection in Ab-neg
Screen blood and organ donors
Detect perinatal infections in babies born to HCV-pos

24
Delta hepatitis, ssRNA (Delta Ag), spherical in shape
HDV
25
A defective virus requires obligatory helper functions from HBV to ensure replication and infectivity.
HDV
26
HBV provides HDV with a protein coat of ?
HBsAg
26
Primarily transmitted by _______ means and is commonly severe
parenteral
27
SIMULTANEOUS infection of HDV with HBV,
Coinfection
28
additional HDV infection in patients with chronic HBV infection
Superinfection
29
without chronic infection
Coinfection
30
with chronic infection
Superinfection
31
Elevated in acute phase
Anti-HDV IgM
31
Produced in the convalescence phase
Anti-HDV IgG
32
Active HDV infection
HDV RNA
32
May be used to monitor effectiveness of therapy
HDV RNA
33
Used to confirm a positive HDV antibody screen
HDV RNA
34
Presence of IgM anti-HDV + HBsAg + IgM anti-HBc
Co-infection
35
Absence of IgM anti-HBc + Positive anti-HDC + IgG Anti-HBc
Superinfection
36
Presence of anti-HD
Chronic infection
37
Family of HEPATITIS E (HEV)
Calciviridae (ssRNA)
38
Calciviridae (ssRNA) in HEV reclassified to
Hepeviridae
39
Presents as an acute, self-limiting hepatitis without progression to chronic state
HEV
40
Current/new hepatitis E infection NM
IgM Anti-HEV
41
Current/former hepatitis E infection FG
IgG Anti-HEV
42
detect px in the later stages of infection; determine past exposure
IgG Anti-HEV
43
identify seroprevalence of the infection in a population
IgG Anti-HEV
43
Current hepatitis E infection
HEV RNA
44
nucleic acid can be performed by realtime PCR or a loop-mediated isothermal amplification assay (LAMP)
HEV RNA
44
can be detected just before clinical symptoms.
HEV RNA
45
becomes undetectable in the blood about 3 weeks after symptom onset; in the stool, it becomes undetectable at about 5 weeks.
HEV RNA
46
A negative result for does not exclude the possibility of a recent infection
HEV RNA
47
2 independent viruses in HGV
HGV and GBV-C
48
Family of HGV
Flaviviridae (ssRNA)

Immunology And Serology BOARD EXAM (32 decks)

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