onco-para neoplastic syndrome

Question 0

Most common para neoplastic syndrome

Answer 0

Hypercalcemia

Question 1

Para neoplastic syndrome

Answer 1

SIADH
Syndrome of ectopic ACTH production
Subacute sensory neuropathy
Hypercalcemia
Hypertrophic pulmonary osteoarthropathy
Hypercoagulable state 
Adrenal insuff
Migratory thrombophlebitis 
Ectopic HCG production
Eaton-Lambert Syndrome
Fever and neutropenia
Clubbing
No bacterial thrombotic endocarditis 
Tumor lysis syndrome

Question 2

Hypercalcemia occurs in about 10% of the cancer patients.. Most commonly in..

Answer 2

Cancer of lungs
breast
head and neck
Kidney 
Myeloma (bone marrow)

Question 3

Most common mechanism of hypercalcemia as para neoplastic syndrome

Answer 3

Bone resorption mediated by parathormone-related proteins

Question 4

S&s in hypercalcemia

Answer 4

Fatigue
Anorexia
Constipation
Weakness

Question 5

Cytokines that acts locally in tumor in pts with hypercalcemia

Answer 5

IL-1
IL-6
Transforming GF-B

Question 6

Syndrome of inappropriate antidiuretic hormone is induced by…

Answer 6

Action of arginine vasopressin produced by certain tumors

Question 7

Most common tumor involved in pts with SIADH

Answer 7

Small cell carcinoma of the lungs

Question 8

SIADH is characterized by

Answer 8

Hyponatremia
Inappropriate concentrated urine
High urine NA secretion in the absence of volume depletion

Question 9

S&s of SIADH

Answer 9

Confusion
Lethargy
Irritability
Personality changes 
Weakness
Anorexia
Depression

Question 10

Causes of adrenal insufficiency

Answer 10

1. Infiltration of adrenals by tumor

2. Adrenal destruction by hemorrhage

Question 11

S&s of adrenal insuff

Answer 11

Nausea and vomiting
Anorexia
Orthostatic hypotension

Question 12

Syndrome of ectopic ACTH secretion is characterized by..

Answer 12

Hyperadrenocorticalism due to ectopic ACTH production

Question 13

S&s of Syndrome of ectopic ACTH secretion

Answer 13

Cushingoid feature
Severe weakness
Hypertension
Edema 
Weight loss

Question 14

It is characterized by proximal limb weakness that improves with repeat contraction

Answer 14

Eaton-lambert syndrome

Question 15

Eaton-lambert syndrome is most commonly asso with…

Answer 15

Small cell lung carcinoma

Question 16

A peripheral neuropathy characterized by progressive involvement of all sensory modalities with areflexia and sensory ataxia

Answer 16

Subacute sensory neuropathy

Question 17

Subacute sensory neuropathy is most commonly asso with…

Answer 17

Small cell lung carcinoma

Question 18

In nonbacterial thrombotic endocarditis, which heart valve is commonly involved?

Answer 18

Mitral valve

Question 19

Nonbacterial thrombotic endocarditis may result to

Answer 19

Emboli to CNS, kidneys and coronary arteries

Question 20

Nonbacterial thrombotic endocarditis is commonly asso with…

Answer 20

Adenocarcinoma

Bronchioalveolar cell Ca

Question 21

It is characterized by the release of large amt of NA breakdown products (chiefly uric acid), K, P, lactic acid due to rapid destruction of tumor cells when rapidly growing tumor are treated with effective chemotherapy regimen.

Answer 21

Tumor lysis syndrome

Question 22

In tumor lysis syndrome, high phosphate may lead to..

Answer 22

Hypocalcemia

Question 23

In tumor lysis syndrome, high uric acid (acidosis) may lead to

Answer 23

Its precipitation in renal tubules which may lead to renal failure which in turn may exacerbate hyperkalemia

Question 24

Chemo pts

Answer 24

NA, Ca, PO4, K, urinalysis