Human Phys 4.6 Flashcards

1
Q

Flow mediated dilation

A

Shear stress increases eNOS stimulation which leads to nitric oxide release from endothelial cells to smooth cells

Once in smooth cells cGMP increases and causes relaxation and vasodilation

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2
Q

How does blood flow in the arteries during diastole to compliance reserves?

A

Recoil of arteries

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3
Q

Hydrostatic capillary pressure use the main starling force that drives what?

A

Fluid filtration

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4
Q

What is the key compound in the FMD used to signal dilation in arteries?

A

eNOS

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5
Q

Functional sympatholysis plays what role in metabolic regulation of blood flow?

A

Decreases metabolite activity stimulating the SNS, but overridden by vasodilation pathways

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6
Q

In what chronic disease is functional sympatholysis impaired?

A

Hypertension

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7
Q

How does blood flow in arteries during diastole?

A

Due to elastic reserves

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8
Q

Why does the venous side get an IV?

A

Because a change in volume does not effect pressure very much

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9
Q

Myogenic autoregulation

A

Sudden stretch of small blood vessels stimulates vascular smooth muscle cells contraction via stretched induced depolarization

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10
Q

What happens in myogenic autoregulation when flow increases?

A

Pressure increases too leading to increased VSMC contraction which increases resistance and decreases flow back to normal

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11
Q

What does metabolic autoregulation override?

A

Myogenic autoregulation

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12
Q

What is myogenic autoregulation governed by?

A

VSMC

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13
Q

What does increase wall stress lead to?

A

Increase VSMC contraction

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14
Q

What does contraction of VSMC cause?

A

Decrease radius and restores wall stress

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15
Q

What is flow mediated dilation governed by?

A

Endothelial cell

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