Infantile Cholestasis Flashcards

1
Q

Cholestasis is defined as _____________ due to _____________ or to _____________ through intra or extra hepatic bile ducts

A

decrease in bile flow

impaired secretion by hepatocytes

obstruction of bile

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2
Q

Infantile cholestasis is defined as _________ occurring within the first _________ of extra uterine life

A

conjugated hyperbilirubinemia

90 days

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3
Q

Surgical jaundice is???

A

Any type of jaundice that is fixable with surgery

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4
Q

Cholestatic jaundice affects approximately 1 in _______ infants globally

• ___________ accounts for 25-35% o f infantile cholestasis globally.

•In LUTH- ________ is the commonest cause o f infantile cholestasis

A

2500

Biliaryatresia

Sepsis

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5
Q

Infantile cholestasis has ____ sex predilection

however biliary atresia shows ________ preponderance, while neonatal
hepatitis is commoner in _____.

A

no

female

males

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6
Q

Pathophysiology of infantile cholestasis

•immaturity of the _________________ in infants

•manifestations of __________________ early in life

•susceptibility of infants _________ to various ________ and _______ stimuli

A

hepatobiliay excretory function

inborn errors of metabolism

immature liver ; infections and toxic

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7
Q

Cholestasis can be classified into _______ and ________

A

Extra hepatic

Intra hepatic

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8
Q

Intra hepatic cholestasis can be divided into __________ and _________

A

Hepatocellular

Obstructive

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9
Q

Etiology o f EXTRAHEPATIC cholestasis

• Extrahepatic ________
• __________ cyst
• Bile duct _________
• Spontaneous _________ of the _______
•____________
• inspissated bile/ mucus plug
• Extrinsic ________________

A

biliaryatresia; Choledochal

stenosis

perforation of the bileduct

Cholelithiasis; compression of the bileduct

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10
Q

Etiology of intrahepatic cholestasis

________
__________
_____________ disorders
Miscellaneous

A

Infections
Metabolic
Endocrine

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11
Q

CLINICAL PRESENTATION of infantile cholestasis

Mention 6

•__________
• Xanhtoma
•________
•—————
•________ stool
• _____ urine
• Pasage of ____________
• Pruritus
• Failure to _______
• Night blindnes • Rickets

A

Jaundice

Hepatomegaly

splenomegaly

Acholic; dark

Bulky stool

thrive

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12
Q

Comparison between biliary atresia and intrahepatic hepatitis

In terms of:

Location
Birth weight
Stool
Associated anomalies
Ultrasonographic finding
Duodenal intubation

A

Post hepatic; intra hepatic

Normal ; pre-term

Persistently acholic; alternating normal and pale

Plenty; rare

Triangular cord sign; absent cord sign

Doesn’t Yield bile stained fluids; yields bile stained fluids

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