Infantile Cholestasis

Question 1

Cholestasis is defined as _____________ due to _____________ or to _____________ through intra or extra hepatic bile ducts

Answer 1

decrease in bile flow

impaired secretion by hepatocytes

obstruction of bile

Question 2

Infantile cholestasis is defined as _________ occurring within the first _________ of extra uterine life

Answer 2

conjugated hyperbilirubinemia

90 days

Question 3

Surgical jaundice is???

Answer 3

Any type of jaundice that is fixable with surgery

Question 4

Cholestatic jaundice affects approximately 1 in _______ infants globally

• ___________ accounts for 25-35% o f infantile cholestasis globally.

•In LUTH- ________ is the commonest cause o f infantile cholestasis

Answer 4

2500

Biliaryatresia

Sepsis

Question 5

Infantile cholestasis has ____ sex predilection

however biliary atresia shows ________ preponderance, while neonatal
hepatitis is commoner in _____.

Answer 5

no

female

males

Question 6

Pathophysiology of infantile cholestasis

•immaturity of the _________________ in infants

•manifestations of __________________ early in life

•susceptibility of infants _________ to various ________ and _______ stimuli

Answer 6

hepatobiliay excretory function

inborn errors of metabolism

immature liver ; infections and toxic

Question 7

Cholestasis can be classified into _______ and ________

Answer 7

Extra hepatic

Intra hepatic

Question 8

Intra hepatic cholestasis can be divided into __________ and _________

Answer 8

Hepatocellular

Obstructive

Question 9

Etiology o f EXTRAHEPATIC cholestasis

• Extrahepatic ________
• __________ cyst
• Bile duct _________
• Spontaneous _________ of the _______
•____________
• inspissated bile/ mucus plug
• Extrinsic ________________

Answer 9

biliaryatresia; Choledochal

stenosis

perforation of the bileduct

Cholelithiasis; compression of the bileduct

Question 10

Etiology of intrahepatic cholestasis

________
__________
_____________ disorders
Miscellaneous

Answer 10

Infections
Metabolic
Endocrine

Question 11

CLINICAL PRESENTATION of infantile cholestasis

Mention 6

•__________
• Xanhtoma
•________
•—————
•________ stool
• _____ urine
• Pasage of ____________
• Pruritus
• Failure to _______
• Night blindnes • Rickets

Answer 11

Jaundice

Hepatomegaly

splenomegaly

Acholic; dark

Bulky stool

thrive

Question 12

Comparison between biliary atresia and intrahepatic hepatitis

In terms of:

Location
Birth weight
Stool
Associated anomalies
Ultrasonographic finding
Duodenal intubation

Answer 12

Post hepatic; intra hepatic

Normal ; pre-term

Persistently acholic; alternating normal and pale

Plenty; rare

Triangular cord sign; absent cord sign

Doesn’t Yield bile stained fluids; yields bile stained fluids