CH. 12: Lecture Question COMPLETE

Question 1

If a soluble protein (i.e. not an
integral membrane protein) is in
the lumen of one compartment and is trafficked by a vesicle to a
second compartment, it will be:

A. In the lumen of the second compartment
B. Free in the cytosol
C. An integral membrane protein
of the second compartment

Answer 1

A. In the lumen of the second compartment

Question 2

The interior of the nucleus (in gray) is topologically equivalent to:

A. The lumen of the ER
B. The lumen of the Golgi
C. The lumen of a
lysosome
D. The extracellular space
E. The cytosol

Answer 2

E. The cytosol

Question 3

The lumen of an endosome is
topologically equivalent to all
these EXCEPT…

A. The lumen of the ER
B. The lumen of the Golgi
C. The lumen of a
lysosome
D. The extracellular space
E. The cytosol

Answer 3

D. The extracellular space

Question 4

A “biochemical factory” formed by a condensate is an example of:

A. A membraneless organelle
B. An organelle enclosed by one or two lipid bilayers

Answer 4

A. A membraneless organelle

Question 5

After engulfment of cytoplasmic
components by autophagy, the contents of the new membrane-enclosed structure are in an area that is equivalent to:

A. The cytosol
B. The lumen of organelles like
endosomes and lysosomes, etc.

Answer 5

B. The lumen of organelles like
endosomes and lysosomes, etc.

Question 6

Abundant smooth ER in some cells is called the sarcoplasmic reticulum.

True or False

Answer 6

True

Question 7

Orientation of positively-charged amino acid side chains around
the internal signal sequence determines which terminus remains in the cytosol.

True or False

Answer 7

True

Question 8

sensing of mis-folded
proteins leads to activation of genes to:
* increase protein- folding capacity
* Increase protein degradation apparatus
* slow translation of most new proteins
All of the above

Answer 8

All of the above

Question 9

ER synthesis of membrane phospholipids takes place in the cytosolic leaflet of the ER membrane.

True or False

Answer 9

True

Question 10

Proteins with NLSs are translated in:

A. Nucleus
B. ER
C. cytosol

Answer 10

C. cytosol

Question 11

If a protein with an NLS is mutated so that the NLS is non-functional, the protein will end up in:

A. ER
B. Mitochondria
C. Nucleus
D. cytosol

Answer 11

D. cytosol

Question 12

Where are importins synthesized?

A. Cytosol
B. nucleus

Answer 12

A. Cytosol
(A importins bind cargo with NLSs
B binding of adaptor protein to cargo with NLS reveals NLS on
adaptor, which is bound by an importing)

Question 13

What enzyme catalyzes transfer of a phosphate group from ATP to a target (e.g. a protein side chain)?

A. Phosphatase
B. Kinase

Answer 13

B. Kinase