Video: 15.7 RAS Flashcards
1
Q
What is RAS?
A
a representation of a large family of GTPase, and functions as a molecular switch
2
Q
What is inactive RAS? (Switch OFF)
A
GDP bound
3
Q
What is active RAS? (Switch ON)
A
GTP Bound
4
Q
How is GTP switched to GDP by Ras?
A
Ras hydrolyses GTP to GDP
5
Q
What does Ras hydrolysis require?
A
RasGAP
6
Q
What does RasGAP do?
A
binds to Ras and inserts Arg 789 side chain
followed by Thr 35, Gln 61
7
Q
What side chains promote GTP hydrolysis of Ras?
A
Arg 789, Th 35, Gln 61
