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PCOL > Drugs for Coagulative Disorders (Part 02) > Flashcards

Drugs for Coagulative Disorders (Part 02) Flashcards

1
Q

Anticlotting Drugs

A
  1. Anticoagulants
  2. Antiplatelets
  3. Thrombolytics
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2
Q

It is used to prevent the formation of clots.

A

Anticoagulants

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3
Q

It is used to inhibit platelet aggregation.

A

Antiplatelets

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4
Q

It is used to dissolve such life-threatening clots.

A

Thrombolytics

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5
Q

Drug/s that Facilitate Clotting

A

Hemostatics

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6
Q

It is used to speed clot formation, or to limit bleeding from surgical site.

A

Hemostatics

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7
Q

It is used to prevent the formation and enlargement of clots.

A

Anticoagulants

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8
Q

Example/s of Anticoagulants

A

• Warfarin (Coumadin)
• Heparin
• Low Molecular Weight Heparin

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9
Q

Action/s of Anticoagulants

A

• Inhibit certain clotting factors.
• Lengthen clotting time.
• Prevent thrombi from forming or growing larger.

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10
Q

Its MOA is to inhibit Vitamin K Synthesis

A

Warfarin

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11
Q

Its MOA is to activate Antithrombin III

A

Heparin

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12
Q

Oral or IV

(Warfarin or Heparin)

A

Warfarin

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13
Q

IV or SC

(Warfarin or Heparin)

A

Heparin

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14
Q

PT-INR

(Warfarin or Heparin)

A

Warfarin

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15
Q

APTT

(Warfarin or Heparin)

A

Heparin

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16
Q

Prophylactic for Acute MI

A

Warfarin

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17
Q

Prevention of Venous Thrombosis

A

Heparin

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18
Q

Antidote for Warfarin

A

Vitamin K

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19
Q

Antidote for Heparin

A

Protamine Sulfate

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20
Q

Other Name of Vitamin K

A

Antihemorrhagic Factor

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21
Q

Vitamin K-1
Vitamin K-2
Vitamin K-3

A

Phylloquinone
Menaquinone
Menadiol

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22
Q

Drug/s under LMWH

A

• Enoxaparin (Lovenox)
• Tinzaparin (Fragmin)
• Dalteparin (Innohep)

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23
Q

Anticoagulants of choice for treating pregnant women with prosthetic heart valves or venous thromboembolism.

A

• Enoxaparin (Lovenox)
• Tinzaparin (Fragmin)
• Dalteparin (Innohep)

24
Q

Anticoagulants under Direct Thrombin Inhibitors

A
  1. Lepirudin (Refludan)
  2. Argatroban
  3. Fondaparinux (Arixtra)
25
Q

Polypeptide that is closely related to hirudin.

A

Lepirudin (Refludan)

26
Q

Prophylactic for the treatment of thrombosis in patients with HIT.

A

Argatroban

27
Q

First in new class of pentasaccharide anticoagulants that is purely synthetic.

A

Fondaparinux (Arixtra)

28
Q

Most common and potentially serious adverse effect is bleeding.

A

Anticoagulants

29
Q

Most common and potentially serious adverse effect is bleeding.

A

Anticoagulants

30
Q

Anticoagulants under Indirect Thrombin Inhibitors

A

• Warfarin (Coumadin)
• Heparin
• Low Molecular Weight Heparin

31
Q

Four (4) Primary Subclasses of Antiplatelets

A
  1. Aspirin (Acetylsalicylic Acid)
  2. ADP Receptor Blockers
  3. Glycoprotein IIA/IIB Receptor Blockers
  4. PDE Inhibitors
32
Q

Irreversible inhibition of COX.

A

Aspirin (Acetylsalicylic Acid)

33
Q

Prophylactic for transient cerebral ischemia and to reduce the incidence of recurrent MI.

A

Aspirin (Acetylsalicylic Acid)

34
Q

A/E of Aspirin (Acetylsalicylic Acid)

A
  1. Increased Incidence of Hemorrhagic Stroke
  2. GIT Bleeding
  3. Salicylism = Tinnitus
35
Q

It is also known as Thienopyridines.

A

ADP Receptor Blockers

36
Q

Irreversibly inhibit the binding of ADP to its receptors on platelets.

A

ADP Receptor Blockers

37
Q

Drug/s under ADP Receptor Blockers

A

• Clopidogrel (Plavix)
• Ticlopidine (Ticlid)
• Prasugrel (Effient)

38
Q

It is the preferred agent in ischemic heart disease events.

A

Clopidogrel (Plavix)

39
Q

It causes Neutropenia / Agranulocytosis, Thrombotic Thrombocytopenic Purpura (TTP), and Aplastic Anemia.

A

Ticlopidine (Ticlid)

40
Q

Drug/s under Glycoprotein IIA and IIB Blockers

A
  1. Abciximab (Reopro)
  2. Eptifibatide (Integrilin)
  3. Tirofiban (Aggrastat)
41
Q

A chimeric monoclonal antibody.

A

Abciximab (Reopro)

42
Q

Drug/s under PDE Inhibitor

A

Dipyridamole

43
Q

It is usually given in combination with aspirin or warfarin; it is ineffective when used alone.

A

Dipyridamole

44
Q

Used to dissolve existing clots.

A

Thromobolytics

45
Q

Three (3) Types of Thrombolytics

A
  1. Streptokinase (Streptase)
  2. Tissue Plasminogen Activator
  3. Anistreplase
46
Q

Protein from Streptococci

A

Streptokinase (Streptase)

47
Q

Derived from Cultured Human Melanoma Cells

A

Tissue Plasminogen Activator

48
Q

Anisoylated Plasminogen Streptokinase Activator Complex

A

Anistreplase

49
Q

Used to promote the formation of clots.

A

Hemostatics

50
Q

Drug/s under Hemostatics

A
  1. Aminocaproic and Tranexamic Acid (Hemostan)
  2. Aprotinin
  3. Desmopressin Acetate
51
Q

Inhibit Plasminogen Activation

A

Aminocaproic and Tranexamic Acid (Hemostan)

52
Q

Potential S/E of Treatment is Intravascular Thrombosis

A

Aminocaproic and Tranexamic Acid (Hemostan)

53
Q

It stops bleeding by blocking plasmin.

A

Aprotinin

54
Q

Approved for prophylactic use to reduce perioperative blood loss and the need for blood transfusion in patients undergoing cardiopulmonary bypass sugery.

A

Aprotinin

55
Q

This is the vasopressin V2 receptor agonist that increases the plasma concentration of von willebrand factor and factor VIII.

A

Desmopressin Acetate

PCOL (21 decks)

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