Drugs for Dyslipidemia (Part 01)

Question 1

A soft waxy substance found among lipids (fats) in the bloodstream and all cells. Needed for digesting fats, making hormones, building cell walls. Carried in particles called lipoproteins that act as transport vehicles delivering cholesterol to various body tissues to be used, stored or excreted.

Answer 1

Cholesterol

Question 2

Excess circulating cholesterol can lead to plaque formation.

Answer 2

Atherosclerosis

Question 3

This catalyze the rate limiting step.

Answer 3

HMG-CoA Reductase

Question 4

For Vitamin D, Steroid Hormones, Bile Acids, Proteins, Cell Membrane

Answer 4

Cholesterol

Question 5

Stores bile acid produced by the liver.

Answer 5

Gallbladder

Question 6

Collects blood from the various segments of the GIT that perfuse in the liver. Carries nutrient to the liver. It also facilitates enterohepatic recirculation / biliary recycling.

Answer 6

Hepatic Portal Vein

Question 7

A tube that carries bile from the liver and the gallbladder through the pancreas and into the duodenum.

Answer 7

Common Bile Duct

Question 8

The cholesterol, triglycerides, and phospholipids are transported in the bloodstream as complexes of lipid and proteins.

Answer 8

Lipoproteins

Question 9

Bad Cholesterol

Answer 9

Low Density Lipoprotein (LDL)

Question 10

The major cholesterol carrier in the blood. Excess most likely to lead to plaque formation.

Answer 10

Low Density Lipoprotein (LDL)

Question 11

Good Cholesterol

Answer 11

High Density Lipoprotein (HDL)

Question 12

Transports cholesterol away from arteries and back to the liver to be eliminated. Removes excess cholesterol from plaques, slowing growth.

Answer 12

High Density Lipoprotein (HDL)

Question 13

It is secreted by the liver and export triglycerides & cholesterol to peripheral tissues. A precursor of LDL.

Answer 13

Very Low Density Lipoprotein (VLDL)

Question 14

A fat that is located deep within your abdominal organs.

Answer 14

Visceral Fat

Question 15

A fat just under the skin.

Answer 15

Subcutaneous Fat

Question 16

It is the chemical form in which most fat exists in foods as well as in the body. Develop when calories are not burned right away and are stored in fat cells. Store unused calories and provide your body with energy.

Answer 16

Triglycerides

Question 17

Formed in the intestine and carry triglycerides from dietary origin.

Answer 17

Chylomicrons

Question 18

Also known as Hyperlipoproteinemia / Dyslipidemia

Answer 18

Hyperlipidemia

Question 19

It describes an increased concentration of the lipoprotein macromolecules that transport lipids in the plasma.

Answer 19

Hyperlipidemia

Question 20

Pathophysiology of Hyperlipidemia

Answer 20

1. Genetic
2. Environment / Lifestyle Factors

Question 21

Two (2) Types of Dyslipidemia (Based on Cause)

Answer 21

1. Primary Dyslipidemia
2. Secondary Dyslipidemia

Question 22

Single or multiple gene mutation resulting in disturbance of LDL, HDL and triglyceride, production or clearance.

Answer 22

Primary Dyslipidemia

Question 23

Four (4) Types of Primary Dyslipidemia

Answer 23

1. Familial Combined Hyperlipidemia
2. Familial Hyper-Apo Beta Lipoproteinemia
3. Familial Hypertriglyceridemia
4. Homozygous Familial

Question 24

It is caused by lifestyle factors, medical conditions that interfere with blood lipid levels over time.

Answer 24

Secondary Dyslipidemia

Question 25

Four (4) Types of Dyslipidemia (Based on Abnormality in Lipid Profile)

Answer 25

1. Hypercholesterolemia
2. Hypertriglyceridemia
3. Chylomicronemia
4. Hypoalphalipoproteinemia

Question 26

“High Cholesterol”

Answer 26

Hypercholesterolemia

Question 27

A medical term for abnormally high levels of cholesterol in the blood. Elevated Total Cholesterol (ETC).

Answer 27

Hypercholesterolemia

Question 28

A condition in which triglyceride levels are elevated. Elevated Triglycerides (TG).

Answer 28

Hypertriglyceridemia

Question 29

A disorder in which the body does not break down fats (lipids) correctly. Deficiency of Chylomicrons.

Answer 29

Chylomicronemia

Question 30

A rare lipoprotein metabolism disorder characterized by deficiency of HDL.

Answer 30

Hypoalphalipoproteinemia