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PCOL > Drugs for Blood Cell Deficiency (Part 02) > Flashcards

Drugs for Blood Cell Deficiency (Part 02) Flashcards

1
Q

A Drug for Iron Deficiency Anemia

A

Iron (Fe)

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2
Q

Total Quantity of Iron in the Body

A

4 g to 5 g

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3
Q

It is the transporter of oxygen in the blood.

A

Hemoglobin

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4
Q

It is the transporter of iron.

A

Transferrin

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5
Q

An iron storage protein.

A

Ferritin

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6
Q

This is the iron and oxygen binding protein found in the skeletal muscle tissue.

A

Myoglobin

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7
Q

A metallo-protein (contains copper and iron) final, enzyme of the electron transport system found in the mitochondria.

A

Cytochrome Oxidase

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8
Q

Two (2) Iron Preparations

A
  1. Oral Iron Preparations
  2. Parenteral Iron Preparations
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9
Q

Drug/s under Oral Iron Preparations

A
  1. Ferrous Sulfate
  2. Ferrous Gluconate
  3. Ferrous Fumarate
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10
Q

325 mg to 65 mg Elemental Iron

A

Ferrous Sulfate

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11
Q

325 mg to 37 mg Elemental Iron

A

Ferrous Gluconate

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12
Q

325 mg to 106 mg Elemental Iron

A

Ferrous Fumarate

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13
Q

Drug/s under Parenteral Iron Preparations

A
  1. Iron Dextran
  2. Iron Sorbitol
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14
Q

It should be reserved for patients with documented iron deficiency that unable to tolerate or absorb iron. With extensive chronic blood loss who cannot be maintained with oral iron alone.

A

Parenteral Iron Preparations

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15
Q

Two (2) Treatments of Iron Toxicity

A
  1. Acute Iron Toxicity
  2. Chronic Iron Toxicity
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16
Q

Drug/s for Megaloblastic Anemia and Pernicious Anemia

A
  1. Vitamin B9 (Folic Acid)
  2. Vitamin B12 (Cobalamin)
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17
Q

Deficiency of either of these vitamins results in impaired production and abnormal maturation of RBCs giving rise the characteristic blood and bone marrow suppression.

A

Vitamin B9 and Vitamin B12

18
Q

Five (5) Brand Names of Vitamin B9 (Folic Acid)

A
  1. Folvite
  2. Folart
  3. Folicard
  4. Hemarate FA
  5. Fortifer FA
19
Q

It is converted to tetrahydrofolate by the action of dihydrofolate reductase.

A

Vitamin B9 (Folic Acid)

20
Q

ROA of Vitamin B9 (Folic Acid)

A

Oral Folic Acid

21
Q

Two (2) Brand Names of Vitamin B12 (Cobalamin)

A
  1. Polynerv
  2. Neurobion
22
Q

Two (2) Available Forms of Vitamin B12 (Cobalamin)

A
  1. Cyanocobalamin
  2. Hydroxocobalamin
23
Q

The active form of B12 is now prescribed for the treatment of vitamin B12 deficiency.

A

Mecobalamin (Methycobal)

24
Q

__________ is absorbed from the GIT in the presence of intrinsic factor of castle.

A

Cobalamin

25
Q

ROA of Vitamin B12 (Cobalamin)

A

Parenteral

26
Q

Drug/s for CKD-Induced Anemia

A
  1. Epoetin Alfa (Epogen, Procrit)
  2. Darbepoetin (Aranesp)
27
Q

__________ is used for anemia associated with renal failure and sometimes effective for patients with other forms of anemia.

A

Erythropoietin

28
Q

A Long-Acting Version of Erythropoietin

A

Darbepoetin (Aranesp)

29
Q

A Drug for Sickle Cell Anemia

A

Hydroxyurea

30
Q

The drug apparently increases fetal hemoglobin levels, thus diluting the abnormal hemoglobin S (HbS).

A

Hydroxyurea

31
Q

A Drug for Megakaryocytes

A

Oprelvekin (Neumega)

32
Q

The recombinant form of an endogenous cytokine.

A

Oprelvekin (Neumega)

33
Q

Two (2) Thrombopoietin Receptor Agonists

A
  1. Romiplostim
  2. Eltrombopag
34
Q

A thrombopoietin receptor agonist with novel peptide structure.

A

Romiplostim

35
Q

An oral agonist of the thrombopoietin receptor.

A

Eltrombopag

36
Q

It stimulate the production and function of neutrophils. GM-CSF also stimulates the production of other myeloid and megakaryocyte progenitors.

A

Granulocyte Colony - Stimulating Factor

37
Q

Used to accelerate the recovery of neutrophils after cancer chemotherapy.

A

Granulocyte Colony - Stimulating Factor

38
Q

Drug/s under Granulocyte Colony - Stimulating Factor

A
  1. Filgrastim
  2. Sargramostim
  3. Pegfilgrastim
  4. Lenograstim
39
Q

The covalent conjugation product of filgrastim and the form of polyethylene glycol.

A

Pegfilgrastim

40
Q

It is used widely in Europe, is the glycosylated form of recombinant G-CSF.

A

Lenograstim

PCOL (21 decks)

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