2 Flashcards
(17 cards)
What do M2 and M3 receptors do?
- M2 –> HR↓
- M3 –> Bronchoconstriction
What do a1 and a2 receptors do?
- a1 –> Vasoconstriction
- a2 –> Vasodilation
What do b1 and b2 receptors do?
- b1 –> HR↑
- b2 –> Bronchodilation
What is a neurotransmitter?
A chemical transmitter that binds to receptors and initiates a response
What is the Parasympathetic Neurotramsmitter?
Acetylcholine
Where can Acetylcholine be found? (4) And what does it do?
- Motor Neurons
- Pre-Ganglionic sympathetic sites
- Sympathetic sweat glands
- Adrenal glands
- They stimulate sweat + adrenal glands
Is Norepinephrine (Levophed) sympathetic or parasympathetic?
Sympathetic, post-ganglionic
Levophed (Norepinephrine)
Where does it go when inactive? What 2 enzymes help with this process?
- Reuptake to pre-synaptic nerve for re-use
- Uptake into surrounding tissue
- Enzymes –> MAO Enzyme+ COMT Enzyme
Acetylcholine
What can deactivate ACh?
- Acetylcholinestrase
- Auto-Receptors
What are the 2 parasympathetic receptor sites?
- Muscarinic Receptors
- Nicotinic Receptors
What does Nicotinic Do? What does it lead to?
- Excite!
- Skeletal Muscle Contraction + CNS Excitation + Vasoconstriction
What are muscarinic receptors? What are the types?
- They are all G-Proteins
- M1, M2, M3, M4, M5 Receptors
What are cholinergic Drugs?
Drugs that can activate or inhibit the muscarinic and/or nicotinic receptors
What are 4 ways cholinergic drugs can act?
- Direct Acting
- Indirect Acting
- Agonist
- Antagonist
What are 2 cholinergic drugs?
- Provocholine (Methacholine)
- Tensilon (Edrophonium)
Provocholine (Methacholine)
Provide its characteristics
- M3 agonist, direct acting
- Bronchoconstriction
Tensilon (Edrophonium)
Provide its times + characteristics
- Onset –> 30sec
- 1/2 Life –> 10min
- Deactivates Acetylcholinesterase –> ↑ACh –> ↑Muscle Control
