2: Biochemistry of the liver Flashcards Preview

Gastrointestinal Week 6 2016/17 > 2: Biochemistry of the liver > Flashcards

Flashcards in 2: Biochemistry of the liver Deck (49)
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1

What are some functions of the liver?

First pass metabolism

Bile production

Detoxification

Secretion of plasma proteins

Storage

2

What is stored in the liver?

Glycogen (fuel)

Metal ions (iron and copper)

Vitamins

3

What is produced by amino acid metabolism in the liver?

Urea

4

Which test separates proteins based on their size and charge?

Electrophoresis

5

Which protein, produced by the liver, is a marker of liver function?

Albumin

6

Alpha and beta globulins are released by the ___ and act as transport molecules.

liver

7

Name the alpha globulin responsible for transporting copper.

Caeruloplasmin

8

Name the alpha globulin responsible for transporting Vitamin A.

Retinol binding protein

9

Which beta globulin transports iron?

Transferrin

10

Which protein acts as an indicator of iron deficiency?

Transferrin

11

What inactive form of a blood clotting agent is produced by the liver?

What is the active agent called?

Which type of globulin is it?

Fibrinogen

Fibrin

Beta

12

What is the most abundant plasma protein found in the blood?

Albumin

13

Albumin is small, water-soluble and (positively / negatively) charged.

negatively charged

14

Why may a patient's albumin levels be low?

Liver disease

Malnutrition (specifically not enough protein)

15

What does albumin transport?

Fatty acids

Bilirubin

Thyroid hormones

16

What antiplatelet drug is transported in the blood by albumin?

Aspirin

17

What is an essential component of haemoglobinmyoglobin and cytochromes?

Iron

18

Which plasma protein transports iron ions?

What form are the iron ions in?

What type of globulin is this plasma protein?

Transferrin

Fe3+

Beta globulin

19

What is the storage form of iron in cells?

Ferritin

20

Which plasma protein transports copper in the blood?

What type of globulin is this plasma protein?

Caeruloplasmin

Alpha globulin

21

What is Wilson's disease?

Deficiency of ceruloplasmin causing copper deposition in liver, brain

22

Steroid hormones are (hydrophilic / hydrophobic).

hydrophobic

23

Can hydrophobic molecules travel in the blood?

No - they require a carrier

24

Can hydrophilic molecules travel in the blood?

Ye

25

Name two hormones which bind to carrier globulins to travel in the blood.

Thyroxine

Cortisol

26

Carrier globulins increase the ___ ___ of hormones, allowing them to work for longer.

half life

27

Which type of molecule transports fat between organs and tissues?

Lipoproteins

28

Name some lipoproteins from least dense to most dense.

Chylomicrons

VLDL
IDL

LDL
HDL

 

29

What does a chylomicron do?

Transports dietary fat to the liver

30

What does LDL do?

Transports cholesterol from the liver to peripheral tissues