7: Pathology of the liver Flashcards Preview

Gastrointestinal Week 6 2016/17 > 7: Pathology of the liver > Flashcards

Flashcards in 7: Pathology of the liver Deck (33)
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1

Blood travels through ___ from the hepatic/portal veins to the central veins in liver cells.

zones

2

The liver has massive ___ potential.

regenerative

3

Why can patients offer halves of their liver for transplant?

Massive regenerative potential

4

By which process does the liver usually heal?

Restitution

5

Which healing process does the liver undergo if it's regenerative potential is overcome, e.g by drugs or alcohol?

Scarring and fibrosis (cirrhosis)

6

What follows the initial insult to hepatocytes e.g viral, drug, toxin?

Inflammation

7

What follows inflammation in liver disease?

Resolution

OR

Chronic inflammation Fibrosis Cirrhosis

8

What is end-stage liver fibrosis called?

Cirrhosis

9

What is seen in hepatocytes during acute liver failure?

Massive necrosis

10

What are the three types of jaundice?

Pre-hepatic

Hepatic

Post-hepatic

11

Bilirubin is ___ if it has passed through the liver and ___ if it hasn't

conjugated , unconjugated

12

What molecule overwhelms the liver in high concentrations and causes pre-hepatic jaundice?

Haemoglobin

13

What causes painless post-hepatic jaundice?

Pancreatic tumours

14

What is end-stage liver disease called?

Cirrhosis

15

Cirrhosis is (reversible / irreversible).

irreversible

16

Cirrhosis is characterised by bands of fibrosis separating the ___ parts of hepatocytes.

regenerative

17

Cirrhosis affects the ___ flow through the liver by altering the vasculature.

blood

18

What does cirrhosis look like?

Compared to smooth liver:

Leathery, craggy, nodular

19

What are the complications of cirrhosis?

Portal hypertension leading to oesophageal/rectal varices and caput medusae

Ascites

Liver failure

20

Low levels of what plasma protein causes ascites in liver disease?

Albumin

21

In alcoholic fatty liver disease, abnormal fat metabolism produces ___ which kill hepatocytes.

toxins

22

Which cells are seen in acute inflammation of the liver?

Neutrophils

23

Which cells lay down the molecule responsible for fibrosis of the liver?

What is this molecule called?

Fibroblasts

Collagen

24

What is seen in hepatocytes in an alcoholic fatty liver?

Steatosis - fatty vacuoles

25

Fatty liver associated with 2-3 days of drinking is (reversible / irreversible).

reversible

26

Is alcohol the only cause of fatty liver disease?

No

27

What else causes fatty liver disease (i.e NASH)?

Pregnancy

Drugs

Obesity

Hepatitis C

28

What is seen in hepatocytes of those with alcoholic hepatitis (week-months of drinking)?

Necrosis

NEUTROPHILS

Mallory bodies

Fibrosis

29

The laying down of which molecule by fibroblasts signals the beginning of liver fibrosis?

Collagen

30

What name is given to the spaces between hepatocytes and sinusoids (blood vessels where hepatic artery and hepatic portal vein mix)?

Space of Disse