Blood travels through ___ from the hepatic/portal veins to the central veins in liver cells.
The liver has massive ___ potential.
Why can patients offer halves of their liver for transplant?
Massive regenerative potential
By which process does the liver usually heal?
Which healing process does the liver undergo if it's regenerative potential is overcome, e.g by drugs or alcohol?
Scarring and fibrosis (cirrhosis)
What follows the initial insult to hepatocytes e.g viral, drug, toxin?
What follows inflammation in liver disease?
Chronic inflammation > Fibrosis > Cirrhosis
What is end-stage liver fibrosis called?
What is seen in hepatocytes during acute liver failure?
What are the three types of jaundice?
Bilirubin is ___ if it has passed through the liver and ___ if it hasn't
conjugated , unconjugated
What molecule overwhelms the liver in high concentrations and causes pre-hepatic jaundice?
What causes painless post-hepatic jaundice?
What is end-stage liver disease called?
Cirrhosis is (reversible / irreversible).
Cirrhosis is characterised by bands of fibrosis separating the ___ parts of hepatocytes.
Cirrhosis affects the ___ flow through the liver by altering the vasculature.
What does cirrhosis look like?
Compared to smooth liver:
Leathery, craggy, nodular
What are the complications of cirrhosis?
Portal hypertension leading to oesophageal/rectal varices and caput medusae
Low levels of what plasma protein causes ascites in liver disease?
In alcoholic fatty liver disease, abnormal fat metabolism produces ___ which kill hepatocytes.
Which cells are seen in acute inflammation of the liver?
Which cells lay down the molecule responsible for fibrosis of the liver?
What is this molecule called?
What is seen in hepatocytes in an alcoholic fatty liver?
Steatosis - fatty vacuoles
Fatty liver associated with 2-3 days of drinking is (reversible / irreversible).
Is alcohol the only cause of fatty liver disease?
What else causes fatty liver disease (i.e NASH)?
What is seen in hepatocytes of those with alcoholic hepatitis (week-months of drinking)?
The laying down of which molecule by fibroblasts signals the beginning of liver fibrosis?
What name is given to the spaces between hepatocytes and sinusoids (blood vessels where hepatic artery and hepatic portal vein mix)?
Space of Disse