10: Pathology of the liver 2 Flashcards Preview

Gastrointestinal Week 6 2016/17 > 10: Pathology of the liver 2 > Flashcards

Flashcards in 10: Pathology of the liver 2 Deck (55)
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1

What microorganism causes hepatitis?

Viruses

2

Name the four common causes of hepatitis.

Hepatitis A, B, C, E

3

Which virus rarely causes hepatitis and is associated with glandular fever?

Epstein-Barr virus

4

Name four viruses, other than Hepatitis, which cause viral hepatitis.

Epstein-Barr virus

Yellow fever virus

Herpes simplex virus

Cytomegalovirus

5

Which virus is spread by the faecal-oral route, causes mild illness and is recovered from quickly?

Hepatitis A

6

Hepatitis A has a (short / long) incubation time.

short

7

Hepatitis A directly kills the hepatocytes rather than generating a immune response which does so - what is the name for this?

Cytopathic

8

Which virus is spread by blood, sexually and vertically?

Hepatitis B

9

Which virus has a long incubation period and is associated by blood contact, sexual contact and in utero?

Hepatitis B

10

Hepatitis B cell damage is (cytopathic / autoimmune).

autoimmune

11

Which virus is spread by blood/sexual contact, has a SHORT incubation time and is much harder to get than Hepatitis B?

Hepatitis C

12

Hepatitis (A/B/C) tends to become chronic.

C

13

Which immune cell is associated with chronic inflammation seen in hepatitis?

Lymphocytes

14

Which substance is stained blue and indicates fibrosis in the Space of Disse?

Collagen

15

What can be seen on the surface of a cirrhotic liver following scarring and fibrosis?

Nodules

16

How does fibrosis affect blood flow in the liver?

Spaces reserved for blood flow fill with fibrosis

⇒ portal hypertension

17

What is a fatal acute outcome of Hepatitis B infection?

Fulminant liver failure

18

What are long term complications of chronic Hepatitis B infection?

Cirrhosis

Hepatocellular carcinoma

19

What are long term complications of Hepatitis C?

Cirrhosis

remember that Hepatitis C has a long incubation period and tends to be assymptomatic

20

Primary biliary cirrhosis / cholangitis

Autoimmune hepatitis

Primary sclerosing cholangitis

all autoimmune diseases

21

Primary biliary cirrhosis (name) is an ___ disease associated with the destruction of mitochondria by ____.

autoimmune

autoantibodies

22

Who tends to get primary biliary cirrhosis?

FFFF

fat fertile females in their 40s

23

What is seen microscopically in primary biliary cirrhosis?

Granulomas

24

Primary biliary cirrhosis is a disease of the ___ ___.

bile ducts

25

What does primary biliary cirrhosis lead to if untreated?

Cholestasis

Inflammation

Fibrosis

Cirrhosis

26

What drugs are used to treat autoimmune hepatitis?

Corticosteroids

Immunosuppressants

27

Why is drug history important in liver and renal disease?

Lots of hepatitis is drug-induced

28

Why may young men develop autoimmune hepatitis?

Drug-induced

protein supplements, bulking etc.

29

Which bile ducts does primary biliary cirrhosis affect?

Small ones within the liver

30

What bile ducts does primary sclerosing cholangitis affect?

Intra and extra-hepatic ducts