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Gastrointestinal Week 6 2016/17 > Bilirubin > Flashcards

Flashcards in Bilirubin Deck (11)
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1

What is bilirubin?

Product of red blood cell breakdown

haemoglobin specifically

2

Where does red blood cell breakdown take place?

Spleen

3

Which component of red blood cells is converted to bilirubin?

Haemoglobin

4

What are the two types of bilirubin?

Unconjugated

Conjugated

5

Where is unconjugated bilirubin formed?

Haemoglobin breakdown in the spleen

6

Where is conjugated bilirubin formed?

What is it produced from?

Liver

Unconjugated bilirubin

7

What causes jaundice?

High blood concentration of bilirubin

8

Which type of bilirubin is elevated in jaundice?

Either or both, depends on where the problem is

9

What are the three types of jaundice?

Pre-hepatic

Intra-hepatic

Post-hepatic

10

Why may a patient have pre-hepatic jaundice?

Indicates high concentration of unconjugated bilirubin in the blood:

Haemolysis - abnormal breakdown of red blood cells

Sickle cell disease - sickle-shaped red blood cells die faster than normal ones

Gilbert's disease - enzyme which converts unconjugated to conjugated doesn't work

11

Why may a patient have intra-hepatic or post-hepatic jaundice?

Increased blood concentration of conjugated bilirubin:

Duct obstruction - bilirubin backs up