Flashcards in  Class 6: Nucleotide Structure/ Metabolism Deck (66)
DNA 5' to 3' gives:
Which carbon of the ribose is deoxy in DNA:
What type of bonds form between A-T and C-G
DNA helix structure
R handed antiparallel 5'-3'
A-T how may h bonds?
2 h bonds
How many h bonds c-g
3 h bonds
Phosphodiester bond, where is it in dna?
Between 3' carbon of ribose and 5' methyl grp on other ribose (below)
Who observed nucleotides in DNA? Who received credit?
Watson and crick received the prize for it though
How many nucleotides in our genome?
How is DNA condensed to fit in our cells?
DNA binding proteins (histones and non-histones) allows for dynamic state between condensation and rapid access for gene expression
Phosphate esters of nucleosides
Contain base, sugar and phosphate
Base + sugar
WHat type of bond is between the purine/pyramidine base and the ribose sugar?
Beta glycosidic linkage
Small name: purine
Big name: pyrimidine
Purine nucleotide base:
Pyramidine nucleotide base:
Cytosine, Uracil, thymine
Cytidine, uridine, thymidine
Difference in thymine and uracil?
2' methyl on thymine,
H on uracil
What are the other purines?
Hypoxanthine, inosine, xanthine, xanthosine
How can you go from a nucleotide to a DEOXYnucleotide?
What stimulates and inhibits ribonucleotide reductase?
ATP stimulates ribonucleotide reductase,
dATP nucleotides inhibits ribonucleotide reductase
Bonds of the 3 phosphates in ATP:
Ester bond on the alpha phosphate and 2 anhydride bonds on beta and gamma phosphates
4 specific roles of nucleotides:
ATP, CoA, NAD+, FAD
DNA bonded together is a phosphodiester bond: another name for this is
A covalent bond
Length between 1 full turn: 34å
10 basepairs /turn
Base pairs are separated by 3.4 å,
36º turn w/ each rotation of a new base pair.
20Å width of DNA
Why is DNA typically in B form: long and slender?
B/c it is typically hydrated in the cell
DNA is more stable w/ more o which base pair?
C-G b/c there are 3 H bonds
Catalyzes the formation of a phosphodiester bridge:
RNA of retrovirus is converted to DNA by what enzyme, and subsequent synthesis of DNA strand?