Flashcards in Lecture 3&4: Seidler AA-bioinformatics Deck (12)
What form AA are found in proteins
Peptide bond is what type of bond
PVT TIM HALL
A gene related to a second gene by descent from a common ancestral DNA sequence
Homologs that perform SAME/ SIMILAR functions in different species. Ex: comparing zebrafish to human
Homologs that perform DIFFERENT functions w/ in one species. Ex: comparing proteins in eye to liver
3 ways to compare Amino acid sequences:
Sliding, Shuffling, and blosum 62
Pair-wise comparison- stacking on top of one another for a numerical number of sameness. Multiply the number of same residues by 10. Helps top identify Gaps. USes a chart that has peak generally in the middle d/t highest number of matches d/t sliding mechanism.
Identify where certain portions of sequence have Been removed or added. Can occur w/ gene duplication and insertions / deletes
Scrambling the sequences multiple times to see the number of alignments (/10 d/t the X 10 of Same residues)
Scores differences in Amino acid properties (highly variant, invariant, and conservative groups). Positive score=positive mutations. Net scores=mutation that changes property of amino acid.