22

Question 1

ratio of aatRNA to RF

Answer 1

5:1

Question 2

faulty decoding

Answer 2

if the incorrect aatRNA comes in or if a RF comes in and stays there for too long when it isnt supposed ot

Question 3

what happens when a mismatched tRNA moves into the P site

Answer 3

triggers conformational changes that decrease fidelity in the A site and early protein synth termination through RF3
protein is degradded

Question 4

major hallmark of aging and age related diseases

Answer 4

loss of proteostasis

Question 5

mutations that alter lifespans

Answer 5

saccharomyces serecisiae Rps2

yeast mitochondria S12 P5OR hypoaccurate mutation

yeast mitochondria S12 K71T hyperaccurate mutation

Question 6

RPS23 protein function

Answer 6

relates to translation accuracy due to its role in domain closure like aatRNA binding which also leads to domain closure and GTP hydrolyss

Question 7

where does the K60R mutation happen

Answer 7

only in thermophilic and hyperthermophylic archaea in the Rps23 KQPNSA region

this inc lifespan and dec stop codon read through

Question 8

what does rapamycin do

Answer 8

coats coronary stents
dec organ transplant rejection
cures rare lung disease

inihbits B and T cells by reducing their sensitivity to IL2 thorugh mTOR inhibition which is also what sirolimus does