Prescribing in liver disease Flashcards
1
Q
Give examples of two substances which undergo saturable kinetics?
A
Phenytoin
Alcohol
2
Q
What sex hormones are not metabolised well with cirrhosis?
A
Aldosterone and estrogen
3
Q
What are the consequences for the kidney in cirrhosis?
A
Potassium loss (hypokalaemic)
Sodium retention
Water retention
4
Q
What causes hepato-renal syndrome?
A
Aldosterone and endothelin causing renal vasoconstriction
5
Q
What are the consequences of moderate hepatic impairment?
A
Gut oedema -poor absorption Liver & kidney congestion -Reduced function Gross oedema & ascites CHF