Prescribing in liver disease Flashcards

1
Q

Give examples of two substances which undergo saturable kinetics?

A

Phenytoin

Alcohol

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2
Q

What sex hormones are not metabolised well with cirrhosis?

A

Aldosterone and estrogen

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3
Q

What are the consequences for the kidney in cirrhosis?

A

Potassium loss (hypokalaemic)
Sodium retention
Water retention

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4
Q

What causes hepato-renal syndrome?

A

Aldosterone and endothelin causing renal vasoconstriction

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5
Q

What are the consequences of moderate hepatic impairment?

A
Gut oedema 
-poor absorption
Liver & kidney congestion
-Reduced function
Gross oedema & ascites
CHF
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