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Flashcards in Hepatitis B Deck (23):
1

What is the earliest indicator of Hep B infection?

Hep B surface antigen

2

How soon does the Hep B surface antigen appear?

Generally appears between 27-41 days but could appear as soon as 14 days

3

Does the Hep B surface antigen persist during the acute illness?

Yes

4

When does the Hep B surface antigen disappear?

1-13 weeks after the onset of biochemical abnormalities

5

What is the most reliable serologic marker of Hep B infection?

Hep B surface antigen

6

Can Hep B surface antigen be present in chronic infection?

Yes

7

Does Hep B vaccination result in a positive Hep B surface antigen?

No

8

What does the presence of the antibody to Hep B surface antigen indicate?

Clinical recovery and immunity to Hep B virus

9

Is the antibody to Hep B surface antigen present in chronic carriers?

No

10

What three things could Antibody to Hep B surface antigen without presence of Hep B surface antigen indicate?

Recovery from HBV infection
Absence of infectivity
Immunity from future HBV infection (i.e succesful immunisation)

11

What does the presence of a Hep B e antigen indicate?

A highly infectious state

12

How soon does Hep B e antigen appear?

Within one week of HB surface antigen.
In acute cases Hep B e antigen disappears before HB surface antigen disappears.

13

Can Hep B e antigen be found without Hep B surface antigen?

No

14

What does it suggest if Hep B e antigen persists for longer than 10 weeks

Progression to chronic carrier state and possible chronic hepatitis

15

What does the antibody to Hep B e antigen indicate?

Decreasing infectivity
It suggests a good prognosis and resolution of the acute infection

16

What does the presence of the antibodies for Hep B c and e antigens in the absence of the antibody for Hep B surface antigen and the hep B surface antigen confirm?

Recent acute infection

17

What antibodies are produced in response to the Hep B core antigen (HB-c)

IgM and IgG

18

What do a) high titres and b) low titres of IgM indicate in Hep B infection?

a) Acute infection
b) ongoing disease, usually chronic active hepatitis

19

How soon does IgM appear after Hep B surface antigen?

4-10 weeks

20

What is the only test that can differentiate between recent and remote Hep B infection on one specimen?

IgM

21

What is indicated when there is IgG anti-HBc and the HB surface antigen?

chronic HBV hepatitis

22

What does IgG anti-HBc without the HB surface antigen indicate?

Infection in the remote past

23

What does presence of HBV DNA indicate?
How is it detected?

Continued infectious state
PCR

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