Flashcards in Hepatitis B Deck (23)
What is the earliest indicator of Hep B infection?
Hep B surface antigen
How soon does the Hep B surface antigen appear?
Generally appears between 27-41 days but could appear as soon as 14 days
Does the Hep B surface antigen persist during the acute illness?
When does the Hep B surface antigen disappear?
1-13 weeks after the onset of biochemical abnormalities
What is the most reliable serologic marker of Hep B infection?
Hep B surface antigen
Can Hep B surface antigen be present in chronic infection?
Does Hep B vaccination result in a positive Hep B surface antigen?
What does the presence of the antibody to Hep B surface antigen indicate?
Clinical recovery and immunity to Hep B virus
Is the antibody to Hep B surface antigen present in chronic carriers?
What three things could Antibody to Hep B surface antigen without presence of Hep B surface antigen indicate?
Recovery from HBV infection
Absence of infectivity
Immunity from future HBV infection (i.e succesful immunisation)
What does the presence of a Hep B e antigen indicate?
A highly infectious state
How soon does Hep B e antigen appear?
Within one week of HB surface antigen.
In acute cases Hep B e antigen disappears before HB surface antigen disappears.
Can Hep B e antigen be found without Hep B surface antigen?
What does it suggest if Hep B e antigen persists for longer than 10 weeks
Progression to chronic carrier state and possible chronic hepatitis
What does the antibody to Hep B e antigen indicate?
It suggests a good prognosis and resolution of the acute infection
What does the presence of the antibodies for Hep B c and e antigens in the absence of the antibody for Hep B surface antigen and the hep B surface antigen confirm?
Recent acute infection
What antibodies are produced in response to the Hep B core antigen (HB-c)
IgM and IgG
What do a) high titres and b) low titres of IgM indicate in Hep B infection?
a) Acute infection
b) ongoing disease, usually chronic active hepatitis
How soon does IgM appear after Hep B surface antigen?
What is the only test that can differentiate between recent and remote Hep B infection on one specimen?
What is indicated when there is IgG anti-HBc and the HB surface antigen?
chronic HBV hepatitis
What does IgG anti-HBc without the HB surface antigen indicate?
Infection in the remote past