Flashcards in Viral diarrhoea and C diff infection Deck (42)
What is the commonest cause of diarrhoea in kids under 3 years old?
How is rotavirus spread?
Person to person
Direct and indirect
When are most cases of Rotavirus contracted?
What effects does Rotavirus have in adults?
Subclinical or mild cases in adults
Which group of patients can be severely affected by Rotavirus?
What are the features of Rotavirus infection?
Range of symptoms- Mild watery diarrhoea to profuse, and the patient can go into shock
Patient may have moderate fever first, then vomiting then diarrhoea.
The diarrhoea is not bloody
It is self limiting and lasts for about a week.
Does rotavirus have a low or a high infectious dose?
Can rota virus survive outside of a host?
Yes, it can survive in the environment
What functions of the bowel are affected by rotavirus?
Absorption and secretion
What complication may children get post rotavirus infection?
What is the effect of this?
This leads to more diarrhoea.
There can be repeat infections which get milder each time.
There can be outbreaks.
How is rotavirus diagnosed?
PCR on faeces
How is rotavirus infection managed?
It is self limiting
Management is rehydration therapy
This is done orally where possible i.e. in mild/moderate disease
Antibiotics should not be prescribed
How can rotavirus be prevented?
An oral, live attenuated vaccine
There are 2 doses at 2 and 3 months
Who is the rotavirus vaccine not given to?
A first dose is not given to babies over 15 weeks old
No dose is give to babies over 24 weeks old
What is norovirus known as?
The winter vomiting disease
However, lately it has been causing illness all year round
Which ages are affected by norovirus?
It is highly infectious
How is norovirus spread?
It can be spread person to person or from contaminated food or water
How long can norovirus survive in the environment for?
It can survive on fomites for days-weeks
What is the reservoir for norovirus?
What symptoms does norovirus cause?
Abrupt and unpredictable onset of symptoms
Explosive and sudden vomiting and diarrhoea
Vomiting can lead to widespread environmental contamination and onward transmission
What is the incubation and duration period of norovirus?
It has a short incubation period of <24 hours
it lasts 2-4 days
How is norovirus diagnosed?
PCR on stool or vomit
How is norovirus managed?
It is self limiting but very unpleasant
Early ward closure, isolation and cohorting required.
Which patients can die partly due to norovirus?
The frail and elderly
What percentage of healthy adults have C difficile in their faeces?
What percentage of hospital patients are colonised with C difficile?
What age group has high levels of C diff in their faeces but are not infected?
What is C diff infection a side effect of?
Antibiotic treatment, as a result of disruption of the normal bowel flora
What does C diff produce?
It produces two toxins:
Toxin A is an enterotoxin
Toxin B is cytotoxic and causes bloody diarrhoea