2.5 - Distribution

Question 1

Drug movement from the central compartment (systemic circulation) going to the peripheral compartments (organs & tissues)

Answer 1

Distribution

Question 2

Objective:

Answer 2

Drug delivery to the biological site of action

Question 3

2 PHYSIOLOGIC Factors

Answer 3

• Cardiac Output

* Regional Blood Flow

Question 4

Volume of the blood pumped out by the ❤️ per minute

Answer 4

Cardiac Output (CO)

Question 5

Fraction of CO delivered to specific organs/ tissues

Answer 5

Regional Blood Flow

Question 6

⬆️Regional Blood Flow

Answer 6

• Liver
• Kidneys
• Lungs
• Heart
• Brain

Question 7

⬇️Regional Blood Flow

Answer 7

• Bones

* Adipose Tissues

Question 8

2 PHARMACOKINETIC Factors

Answer 8

• Volume of Distribution

* Protein Binding

Question 9

Volume of Distribution (Vd)

Answer 9

⬆️Vd = ⬆️Distribution

Question 10

Total Body Fluid

Answer 10

60%

Question 11

Intracellular Fluid

Answer 11

40%

Question 12

Extracellular Fluid

Answer 12

20%

Question 13

Interstitial

Answer 13

15%

Question 14

Intravascular

Answer 14

5%

Question 15

Types of Blood Proteins

Answer 15

• Albumin
• a1-acid Glycoprotein
• Globulin

Question 16

– Dominant
– Non-selective
– for weak ACIDS

Answer 16

Albumin

Question 17

– for weak BASED

– Non-selective

Answer 17

A1-acid Glycoprotein

Question 18

– Selective

– For hormones only

Answer 18

Globulin

Question 19

Consequences of Protein Binding

Answer 19

– Longer DOA
– Limit access to certain body compartments
– Potential for drug displacement interaction

Question 20

⬆️ Protein Bound

Answer 20

• Warfarin
• Midazolam
• Diazepam
• NSAIDs
• Sulfa drugs

Question 21

Protein binding

Answer 21

⬆️Protein binding = ⬇️Distribution