3.06 Hemostasis

Question 0

Lyses or dissolves the clot

Answer 0

Fibrinolytic system

Question 1

First cellular evidence when there is a break in the endothelium to stop the bleeding

Answer 1

Platelet system

Question 2

It is the reactive lining of the blood vessel

Answer 2

Basement membrane

Question 3

Helps with platelet adhesion and aggregation and it releases tissue factor which plays a significant part in the clotting cascade

Answer 3

vWF

Question 4

Down regulates thrombin formation and prostacyclin

Answer 4

Protein C

Question 5

A potent vasodilator that resumes original blood flow; inhibits platelet aggregation in healthy vessels

Answer 5

Prostacyclin

Question 6

The first response to an injury

Answer 6

Blood vessel contraction

Question 7

For platelet adhesion, platelet should bind to the vWF through the ______ and to collagen through the _______

Answer 7

Gp1b receptor. Gp1a receptor.

Question 8

Stimulates platelet aggregation. (2 factors)

Answer 8

ADP and Ca2+

Question 9

Stimulates vascular spasms

Answer 9

Thromboxane A2

Question 10

Clotting factor that do not usually participate in clotting in vivo

Answer 10

XII

Question 11

At each stage, a precursor is converted to an activated protease in the presence of these two factors

Answer 11

Calcium and phospholipid factors

Question 12

2 factors that must be present in the liver for this cascade to proceed to completion.

Answer 12

Calcium ions and Vitamin K.

Question 13

Converts soluble fibrinogen into soluble fibrin

Answer 13

Thrombin

Question 14

Factor that is responsible for the mesh formation of the clot

Answer 14

Factor XIII

Question 15

Merger of the extrinsic and intrinsic pathways.

Answer 15

Common pathway

Question 16

Which between the intrinsic and extrinsic pathway is the feedback loop?

Answer 16

Intrinsic pathway

Question 17

Inhibits thrombin formation and Factor Xa. Absence of this results thromboembolism or thrombotic episodes.

Answer 17

Antithrombin

Question 18

Inactivated factor Va and VIIa from resulting to the inhibition of the formation of a fibrin clot. Deficiency in these results to successive clotting.

Answer 18

Activated protein C and S.

Question 19

Binds to thrombin and decreases its ability to produce fibrin

Answer 19

Thrombomodulin

Question 20

Interrupt the hemostatic process on several levels

Answer 20

Calcium chelators (in vitro)

Question 21

Affects post translational modulation (PTM) and give rise to dysfunctional factors that will prevent proper clot formation

Answer 21

Vitamin K antagonists (In vivo)

Question 22

Inactivated thrombin and factor Xa. Neutralized by protamine. PT and aPTT prolonged.

Answer 22

Heparin

Question 23

Vitamin K dependent factors

Answer 23

10, 9, 7, 2

Question 24

Proceeds upon activation of plasmin.

Answer 24

Fibrinolysis

Question 25

A clot in an unbroken vessel

Answer 25

Thrombus

Question 26

A clot, air bubble, lipid droplet, or a thrombus moving through a vessel and possibly lodging anywhere i the vascular system

Answer 26

embolus

Question 27

Anti coagulant (specifically vitamin K dependent factors)

Answer 27

Warfarin

Question 28

Inhibits thrombin and factor Xa

Answer 28

Warfarin

Question 29

Virchow's Triad

Answer 29

V ascular trauma I ncreased coagulability R educed blood flow

Question 30

T/F A negative family history (2-3generations) rules out inherited bleeding disorders.

Answer 30

False

Question 31

Small pinpoint hematoma that is 1-2mm in diameter; generally caused by minor hemorrhage

Answer 31

Petechiae

Question 32

A bruise about 1cm in diameter, generally round in shape; caused by bleeding under the skin

Answer 32

Purpura

Question 33

>3cm in size; commonly called a bruise

Answer 33

Ecchymoses

Question 34

Deal seated collection of clotted blood in an organ, tissue, space or cavity; bleeding into cavities

Answer 34

Hematoma

Question 35

Bleeding in a joint cavity

Answer 35

Hemarthrosis

Question 36

``` Which of the following is an inherited vascular disorder? A. Senile Purpura B. Hemangioma C. Henoch-Schonlein Syndrome D. Scurvy ```

Answer 36

B.

Question 37

Deficiency of platelets in the Blood.

Answer 37

Thrombocytopenia

Question 38

Characterized by small and hypo chromic (paler than usual) red blood cell. leads to prolonged blood loss if left untreated.

Answer 38

Microcytic Anemia

Question 39

Anemia characterized by normal MCV but hematocrit and hemoglobin levels decreased.

Answer 39

Normocytic Anemia

Question 40

Normal platelet count

Answer 40

150-400 x10^9 per liter

Question 41

Normal bleeding time

Answer 41

2-8minutes

Question 42

aPTT measures what pathway?

Answer 42

Intrinsic pathway and common pathway

Question 43

PT measures what?

Answer 43

Extrinsic pathway and Common pathway

Question 44

Time required to form a clot when thrombin is added to the plasma is a measure of Fibrin formation.

Answer 44

Thrombin Time

Question 45

Deficiencies associated with clinical bleeding.

Answer 45

Factors VIII, IX, XI

Question 46

Substitute for bleeding time, stimulate primary hemostasis, superior to bleeding time.

Answer 46

PFA-100 Platelet Function Screen