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Micro > Hepatitis viruses > Flashcards

Hepatitis viruses Flashcards

1
Q

all hepatitis viruses target ?

A

liver

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2
Q

all hepatitis viruses primarily infect and replicate where

A

hepatocytes

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3
Q

what is the family, genome, and virion of hepatitis A

A

family - picornoviridae
genome - (+) ssRNA
virion - nonenveloped

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4
Q

what routes of transmission can ALL hepatitis virus be spread

A

Sexual and parenteral (injection)

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5
Q

hepatitis A can be transmitted in what ways

A

sexual, parenteral, fecal-oral

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6
Q

what is the incubation period for HAV

A

15-40 (short)

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7
Q

what 2 hepatitis virus are known for having short incubation periods

A

hep A

hep E

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8
Q

which hepatitis viruses are known for having long incubation periods

A 
hep B (60-180)
hep C (60-120)
hep D (60-180)
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9
Q

what is the family, genome, and virion of hepatitis B

A

family - hepadnaviridae
genome - circular dsDNA (unique)
virion - enveloped

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10
Q

what hepatitis virus has a DNA genome

A

hep B (circular dsDNA)

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11
Q

what hepatitis virus has a (-) ssRNA genome

A

hep D

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12
Q

how can hep B be transmitted

A

sexual, parenteral, vertical

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13
Q

what family of viruses must use reverse transcriptase ? why ?

A

hepadnaviridae

-b/c has an RNA intermediate

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14
Q

what hepatitis virus has the smallest genome of all human viruses

A

hep B

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15
Q

what hepatitis virus infection increases the risk of developing hepatocellular carcinoma (HCC)

A

hep B

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16
Q

what hepatitis has a vaccination and what is unique about this vaccine

A

hep B

-requires multiple innoculations

17
Q

what hepatitis virus requires an activated HBV infection in order to replicate

A

hep D (rare in humans)

18
Q

chronic hepatitis infections occur in what hepatitis viruses

A 
hep B (5%)
hep C (80%)
hep D
19
Q

what percentage of hepatitis B infections become chronic

A

5 %

20
Q

what percentage of hepatitis C infections become chronic

A

80 %

21
Q

what is the family, genome, and virion for hepatitis C infections

A

family - flaviviridae
genome - (+) ssRNA
virion - enveloped

22
Q

what hepatitis virus can cause extrahepatic disease mixed cryoglobulinemia

A

HCV

23
Q

what hepatitis viruses would you suggest interferon-alpha treatment ?

A

hep B
hep C
- reduces chances for chronic infections

24
Q

what hepatitis viruses could exhibit long term sequelae

A

HBV
HCV
HDV

25
Q

what hepatitis viruses are very rare in the US

A

HDV

HEV

26
Q

what is the family, genome, and virion of Hep D

A

family - deltaviridae
genome - (-)ssRNA
virion - enveloped

27
Q

what is the family, genome, and virion of Hep E

A

family - calciviridae
genome - (+)ssRNA
virion - nonenveloped

28
Q

what hepatits virus has the highest percentage of individuals being seropositive in the US (have Ab to the virus)

A

Hep A

29
Q

what hepatitis virus has the highest statistics of causing chronic liver disease death in the US

A

Hep C

30
Q

what hepatitis virus has the most acute cases in the US

A

Hep B

31
Q

which hep viruses can can be transmitted via fecal to oral

A

HAV
HEV
-NOT vertical though

32
Q

which hep viruses can be transmitted vertically from mom to baby

A

HBV
HCV
HDV

Micro (22 decks)

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