Herpesvirus and Papillomavirus

Question 1

what is the family, genome, and virion of both Type 1 and Type 2 Herpes Simplex

Answer 1

family - alphaherpesvirus
genome - dsDNA
virion - enveloped

Question 2

what is the difference b/w alphaherpesvirus and beteherpesvirus with regards to length of reproduction cycles

Answer 2

alphaherpesvirus - short reproduction cycles allowing for rapid spread in culture
betaherpesvirus - long reproduction cycles

Question 3

what is the difference b/w HSV-1 and HSV-2 w/regards to where they affect the human

Answer 3

HSV-1 above the waist

HSV-2 below the waist

Question 4

what type of herpes virus is unique in that only 1/3 of infected people show symptoms ? Why is this ?

Answer 4

Alphaherpesvirus, b/c many people’s immune systems can handle the infection w/o showing any symptoms

Question 5

what is the difference b/w alphaherpesvirus and beta/gammaherpesvirus with regards to the host range it can affect

Answer 5

alphaherpesvirus - large host range

beta/gammaherpesvirus - restricted host range

Question 6

what drug should be used to treat alphaherpesvirus, but will NOT eliminate latent infections

Answer 6

acylovir

Question 7

what is the common name of the virus from the betaherpesvirus family

Answer 7

cytomegalovirus (CMV)

Question 8

what is the common name of the virus from the gammaherpesvirus family

Answer 8

Epstein-Barr virus (EBV)

Question 9

what are the 2 EBV associated carcinomas ?

Answer 9

• Burketts lymphoma

- Hodgkins lymphoma

Question 10

Betaherpesvirus or CMV have the ability to compromise what host immune functions ?

Answer 10

• Block cell death (inhibit apoptosis)
• decrease NK cell activity
• decrease antigen presentation

Question 11

Alphaherpesvirus or HSV-1 and HSV-2 have the ability to compromise what immune function ?

Answer 11

• Block cell death (inhibit apoptosis)
• decrease NK cell activity
• decrease antigen presentation

Question 12

gammaherpesvirus or EBV have the ability to compromise what immune function ?

Answer 12

• Block cell death (inhibit apoptosis)

- decrease antigen presentation

Question 13

what specific herpes virus persists in hematopoeitic progenitor cells, causing a chronic persistence (not latency)

Answer 13

CMV

Question 14

where do EBV genome cells persist ?

Answer 14

memory B cells

Question 15

Of all types of herpesvirus, which 2 are known to be self-limiting or not that severe

Answer 15

beta/gammaherpesviruses

-CMV and EBV

Question 16

what is the family, genome, and virion of human papillomavirus

Answer 16

family - papilloviridae
genome - dsDNA
virion - nonenveloped

Question 17

Human papillomavirus gains access through the _____, and needs active _____ cells in the host in order to replicate

Answer 17

skin,

basal lamina

Question 18

how can the human papillomavirus be transmitted

Answer 18

skin to skin contact and fomites

Question 19

what are the generic symptoms for all strains of the human papillomavirus

Answer 19

warts

Question 20

if the human papillomavirus was to become oncogenic, what pathways would it have BLOCK to keep cell proliferation constant

Answer 20

-pRb pathway via E7

p53 pathway via E6

Question 21

oncogenesis of human papillomavirus results in what type of cancer

Answer 21

cervical canver

Question 22

most treatments for human papillomavirus are ablative, what does this mean

Answer 22

-burned off, cut off, lasered off

Question 23

what is the name of the vaccine for Human papillomavirus

Answer 23

gardasil (Merck)