Cytokine messanger systems: slides 9-13

Question 1

cytokines and acute inflammation

pro-inflammatory cytokines

Answer 1

IL-1, TNF-alpha, IL-6, IL-8, IL-11, IL-12, IL-15, IL-18

Question 2

What kind of transcription factor is associated with proinflammatory cytokines?

Answer 2

NFkB

they are NF-kB dependent

Question 3

anti-inflammatory cytokines are what

Answer 3

IL-10, TNF-beta

Question 4

What term is used to describe anti-inflammatory cytokines?

Answer 4

they are NF-kB independent

Question 5

who are the major pro-inflammatory cytokines?

Answer 5

IL-1, IL-6, TNF

Question 6

Local & Systemic

Answer 6

cytokines may work locally but can also promote systemic inflammation

Question 7

What two cytokines are known to produce fever, systemic inflammation, and shock/death?

Answer 7

IL-1 and TNF

Question 8

How are IL-1 and TNF “toned down” by the body?

Answer 8

neutralizing antibodies, soluble receptors, receptor antagonists

Question 9

a patient has sepsis: how successful would they be at using anti-IL1/TNF approaches?

Answer 9

not successful.

Question 10

TNF/IL-1 –> local effects (vascular endothelium)

Answer 10

upregulation of leukocyte adhesion molecules
pro-coagulation AND anti-coagulation (???!?!)
production of IL-1/chemokines by endothelia

These are all listed as “inflammation”

Question 11

TNF/IL-1–> local effects (leukocytes)

Answer 11

Activation, production of cytokines

listed as “inflammation”

Question 12

TNF/IL-1–> local effects (fibroblastS)

Answer 12

proliferation
collagen synthesis

listed under “repair”

Question 13

TNF/IL-1 –> systemic effects

Answer 13

Fever, leukocytosis,
upreg. of acute phase proteins
increasing sleep
decrease in appetite