IL-2 and TH1/TH2 differentiation Flashcards
What cytokine controls T cell proliferation?
IL-2
IL-2 induces a low affinity receptor on naive T cells
IL-2R(beta)(gamma)(C)
APC-Tcell w/co stimulation induces
autocrine IL-2 stimulation, and express the alpha chain of the IL-2R(beta)(gamma)((C)
the out come is the high affinity receptor IL-2R(alpha)(beta)(gamma)(C)
IL-2 + high affinity receptor IL-2R(alpha)(beta)(gamma)(C) –>
T cell proliferation
As Ag declines, the number of ___ receptors decline
IL-2R
TGF-beta blocks
IL-2 induced proliferation
IL-12 induces Th0 cells into
Th1 cells
Th1 cells secrete (typically) _____ and promote
IL-2, IFN-gamma, TNF-beta, and promotes cell mediated immunity
IL-4 induces differentiation of _______ cells
Th2 cells which secrete L-4, IL-5, IL-6, IL-10, IL-13
Th2 cells activate
B-lymphocytes resulting in Ab production
Th1 and Th2 cells have mutually _____ effects
inhibitory effects on the reciprocal phenotype
IFN-gamma inhibits ___ T cells
Th2 prolif
IL-10/IL-4 inhibit ____ T cells
Th1 cell prolif
What is the role of dendritic cells in differentiation?
different subsets stimulate the diff. phenotypes
DC –IL-12–> ____ T cells
Th1
