Anti-inflammatory cytokines Flashcards
Major anti-inflammatory cytokines
IL-10, IL-1a, and TGF-beta
IL-10, IL-1a, TNF-beta do what
inhibit the proinflammatory response
Il-10
Produced by….
B cells, T cells, Mac
IL-10
Inhibits ….by mononuclear phagocytes
the following in mononuclear phagocytes:
IL-1beta IL-6 IL-8 IL-12 TNF-alpha
IL-10
inhibits …. in APCs
class II MHC by APCs
costimulatory molecules like CD80/CD86 by APCs
IL-10 inhibits what cytokines from Th1 lymphocytes?
another way to ask is this: what major players in cellular immunity are inhibited by IL-10?
IFN-gamma and TNF-beta
IL-10 inhibits what cytokines in Th2 lymphocytes?
IL-4 and IL-5
IL-10 controls what element in allergic reactions?
tolerance to environmental allergens
TGF-beta…what makes this one unique?
most pleiotropic of the cytokines: has both stimulatory and inhibitory effects on numerous cells?
TGF-beta is produced mainly by
macrophages and T-regulatory cells
TGF beta inhibits proliferation of
B cells and CD8 lymphocytes
TGF-beta inhibits two kinds of cells closely associated with innate immunity
macrophages and NK cells
TGF-beta induces apoptosis in
B cells and CD8 T lymphocytes
TGF-beta regulates the differentiation of
Th17 cells
