4.4_1 Renal I Part II Flashcards Preview

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Flashcards in 4.4_1 Renal I Part II Deck (28):
1

In a normal capillary bed, _____ is high pushing out

HP
OP

2

In a peritubular capillary, _____ is very low

HP

3

What does the low HP in peritubular capillaries yield?

Net reabsorption of water

4

OP is a stronger force in peritubular capillaries because of..

Proteins

5

~_____ % of filtrate is immediately captured from the filtrate

65

6

~___% of Na+ ion reabsorption occurs in the proximal tubule via __________ using the ________

65
Primary active transport
Na+ / K+ ATPase

7

Most other ions (Cl-, K+, Ca2+, Mg2+, Pi) are absorbed from the proximal tubule via _______ or _______

Facilitated diffusion
Secondary active transport

8

Glucose and amino acids are reabsorbed by ....

Carrier mediated secondary active transport with Na+ ions

9

Na+ transport across luminal or apical membrane is ______

Passive (facilitated diffusion)

10

Na+ transport across the basolateral membrane is...

Active (ATPase pump) creates a low intracellular [Na]

11

The luminal membrane is closer to / touching the...

Tubular fluid

12

The basolateral membrane is closer to / touching...

Interstitial fluid

13

Glucose and amino acids are transported by what process across the luminal membrane?

Secondary active transport (supporter proteins, use Na+ gradient)

14

Glucose and amino acids cross the basolateral membrane via..

Facilitated diffusion

15

Maximum tubular transport

Carrier proteins like the Na / Glucose supporter can saturate if the maximum transport capacity (tubular maximum) is exceeded

16

Tubular maximum for glucose

320 mg / min

17

Tubular secretion is for..

Larger, unwanted molecules

18

Tubular secretion is going from the ____ to the ______

Blood
Filtrate

19

Tubular secretion is he..

Active transfer fo materials from peritubular capillaries to lumen of both the PCT and DCT (filtrate)

20

Two generic carrier systems for tubular secretion

Basic carriers
Acidic carriers

21

Basic carriers

For basic molecules
ex: dopamine, histamine

22

Acidic carriers

For acidic molecules
ex: uric acid, sulfate conjugates, penicillin

23

Tubule cells can modify molecules to make them more...

Water soluble and biochemically "inert"

24

Sulfation

Steroid hormones get conjugated with SO2- (sulfates)

25

Many hydrophobic molecules also leave the body through...

Liver bile

26

Cytochrome enzymes

In tubule cells, work to detoxify xenobiotic compound (ex: antibiotic drugs

27

Nephrotoxic

Presence of some drugs kills tubule cells

28

Examples of nephrotoxic drugs

Amphotericin B (anti fungal)
Cisplatin (Chemo)