45 - Stable Angina Flashcards Preview

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Flashcards in 45 - Stable Angina Deck (20):
1

non-pharms

-aggressive lifestyle intervention
-revascularization (PCI or CABG)

2

List 3 classes of drugs used to decrease or prevent angina

-Nitrates
-Beta blockers
-CCBs

*any of these are 1st line but everyone should have SL nitroglycerin on hand for tx of acute angina attack

3

How do nitrates work?

reduce preload and myocardial oxygen demand

4

Long-acting formulations of nitrates frequently case _______

headache

5

Tolerance to the anti-anginal effects of nitrates develops unless a nitrate free period of _____ hours is prescribed each day

10-12

6

How do BBs work?

decrease HR, contractility and BP

they prevent and decrease angina by decreasing myocardial oxygen demand

7

What type of CCB act similar to BBs?

Non-DHPs:
-act more centrally and behave similar to BBs (decrease oxygen demand by decreasing HR, contractility and BP)

8

How do DHP CCBs work?

primarily cause arterial dilation

9

Examples of Non-DHPs

diltiazem, verapamil

10

Example of DHPs

amlodipine, felodipine, nifedipine

11

All 3 DHPs have been used for this indication but which DHP does not have approval for stable angina?

felodipine

12

Other agents:
How does Nicorandil work?

dilates arterioles and veins

13

Other agents:
How does Ranolazine work?

decreases calcium overload

14

Other agents:
How does Trimetazidine work?

inhibits fatty acid oxidation

15

Other agents:
How does Ivabradine work?

inhibits If current

16

Which of the "other agents" listed has approval in HC?

only ivabradine which is approved for patients with HF

17

Patients with stable angina can benefit from drugs that decrease risk of CV death and non fatal MI. Which drug classes are used for this purpose?

-antiplatelet therapy
-statin tx
-ACEi

18

Which antiplatelet does not require hepatic activation?

ticagrelor

19

What are some drugs that increase risk of CV death and nonfatal MI and should not be used?

-hormone therapy
-COX-2 inhibitors and most NSAIDs

20

For prinzmetal angina, what should you use?

use CCB or nitrates

*avoid BBs

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