Flashcards in 45 - Stable Angina Deck (20):
-aggressive lifestyle intervention
-revascularization (PCI or CABG)
List 3 classes of drugs used to decrease or prevent angina
*any of these are 1st line but everyone should have SL nitroglycerin on hand for tx of acute angina attack
How do nitrates work?
reduce preload and myocardial oxygen demand
Long-acting formulations of nitrates frequently case _______
Tolerance to the anti-anginal effects of nitrates develops unless a nitrate free period of _____ hours is prescribed each day
How do BBs work?
decrease HR, contractility and BP
they prevent and decrease angina by decreasing myocardial oxygen demand
What type of CCB act similar to BBs?
-act more centrally and behave similar to BBs (decrease oxygen demand by decreasing HR, contractility and BP)
How do DHP CCBs work?
primarily cause arterial dilation
Examples of Non-DHPs
Example of DHPs
amlodipine, felodipine, nifedipine
All 3 DHPs have been used for this indication but which DHP does not have approval for stable angina?
How does Nicorandil work?
dilates arterioles and veins
How does Ranolazine work?
decreases calcium overload
How does Trimetazidine work?
inhibits fatty acid oxidation
How does Ivabradine work?
inhibits If current
Which of the "other agents" listed has approval in HC?
only ivabradine which is approved for patients with HF
Patients with stable angina can benefit from drugs that decrease risk of CV death and non fatal MI. Which drug classes are used for this purpose?
Which antiplatelet does not require hepatic activation?
What are some drugs that increase risk of CV death and nonfatal MI and should not be used?
-COX-2 inhibitors and most NSAIDs