6 - Depression Flashcards Preview

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Flashcards in 6 - Depression Deck (21):
1

How long do you need to treat for once in remission?

6-9 months

if severe, recurrent, chronic, etc. then do 2 years treatment

2

Non-pharms?

therapy, exercise

3

For pharmacologic treatment:
Min therapeutic dose should be reached in first ___ weeks of treatment and then increase if necessary over the next 4-6 weeks

2

4

side effects of SSRIs

GI, CNS, sexual dysfunction

*sexual dysfunction is more likely to stay all throughout treatment, while GI and CNS side effects will improve

5

At high doses of venlafaxine, what can happen?

can increase BP @ doses > 225 mg/day

*monitor BP and avoid in those with uncontrolled HTN

6

What is the active metabolite of venlafaxine?

desvenlafaxine

7

Bupropion also used for ?

also used for smoking cessation

8

who is bupropion CI in ?

-those with history of or current anorexia or bulimia
-those with history of or current seizure disorder

9

s/e of bupropion

-less GI disturbance compared to SSRIs
-no sexual s/e

10

Bupropion + _____ decreases seizure threshold

alcohol

11

s/e of mirtazapine?

-sedation and weight gain

*less risk of GI and sexual s/e

12

Avoid irreversible MAOis with _____ containing foods

tyramine

*cheese, meats, ripe fruit

13

Washout period:
Irreversible MAOi to any other antidepressant

2 weeks

14

Washout period:
Any other antidepressant to irreversible MAOi

5 half lives

15

Washout period:
From moclobemide to any other antidepressant

5 day washout

16

Washout period:
Fluoxetine to an irreversible MAOi

5 weeks

17

Can also use _____ for depression

antipsychotics

18

Which NHPs are proven effective for mild depression?

-St. John's Wort
-SAM-e

*both can increase risk for serotonin syndrome when used with other serotonergic meds

19

Choice for depression in pregnancy?

-SSRIs

*not paroxetine

20

Choice for depression in breastfeeding?

sertraline, escitalopram or citalopram

*paroxetine and sertraline are detected in low amounts in breast milk

21

When do you assess for remission?

6-8 weeks after they are at therapeutic dose

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