40 - Intermittent Claudication Flashcards Preview

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Flashcards in 40 - Intermittent Claudication Deck (13):
1

key characteristic?

pain is induced by exericse and relieved with rest

2

non-pharms

-stop smoking
-time (collateral flow develops over 6-12 months)
-non-drug tx of obesity, lipid disorders, HTN and associated conditions that increase risk for PAD
-dynamic leg exercises
-endovascular procedures may be helpful

3

In this chapter there are drugs to treat reduce ___ risk and drugs to specifically treat intermittent claudication

CV

4

What are some options we have to decrease CV risk?

-Antiplatelet agents (ASA, clopidogrel, ticagrelor)
-Ramipril
-Beta blockers
-Statins

5

______ agents decrease RR of vascular death in high risk patients by about 25%

antiplatelets

6

How does ramipril help intermittent claudication?

decreases ischemic events and increases walking time and distance

7

How does beta blockers help?

-Decreases risk of MI and death in those with atherosclerosis but may worsen PAD symptoms
-Does not help with walking
-Ok for treating HTN in this population but not for those > 60 yo unless other indication

8

How can statins help intermittent claudication ?

statins decrease CV risk in patients with atherosclerosis and may improve symptoms and walking distance

9

Specific therapy for intermittent claudication:
List 2 drugs

-Pentoxifylline
-Cilostazol

10

Specific therapy for intermittent claudication:
How does pentoxifylline work?

alters erythrocyte deformability and reduces blood viscosity, platelet reactivity and plasma hypercoagulability

*not recommended for mild claudication

11

Specific therapy for intermittent claudication:
How long do you give pentoxifylline for?

give for 24 weeks then 8 week drug period can decrease or eliminate the need for pentoxifyllin

12

Specific therapy for intermittent claudication:
How does Cilostazol work?

-inhibits platelet aggregation by selectively inhibiting phosphodiestase 3
-vasodilator

*improves maximal treadmill walking distance

*not available in Canada

13

Which specific therapy for intermittent claudication is available in Canada?

pentoxifylline

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