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Step 1 > Pharm 8 > Flashcards

Pharm 8 Flashcards

2
Q

Neurotoxicity with isoniazid (INH) prevented by

A

Administration of Vit. B6 (pyridoxine)

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3
Q

Toxicity of amphotericin

A

Nephrotoxicity

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4
Q

SE seen only in men with administration of ketoconazole

A

Gynecomastia

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5
Q

Topical DOC in impetigo

A

Topical mupirocin (Bactroban)

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6
Q

DOC for CMV retinitis

A

Ganciclovir

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7
Q

SE for ganciclovir

A

Myelosuppression

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8
Q

Anti-viral agents associated with Steven-Johnson syndrome

A

Nevirapine, amprenavir

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9
Q

Antivirals that are teratogens

A

Delavirdine, efavirenz, and ribavirin

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10
Q

Antivirals associated with neutropenia

A

Ganciclovir, zidovudine, saquinavir, and interferon

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11
Q

HIV med used to reduce transmission during birth

A

AZT (zidovudine)

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12
Q

Drug used for African sleeping sickness

A

Suramin

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13
Q

Drug used in Chagas disease

A

Nifurtimox

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14
Q

Cephalosporins able to cross the BBB

A

Cefixime (2nd) and 3rd generation

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15
Q

Cephalosporin causes kernicterus in neonates

A

Ceftriaxone or cefuroxime

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16
Q

SE of INH

A

Peripheral neuritis and hepatitis

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17
Q

Aminoglycoside that is least ototoxic

A

Streptomycin

18
Q

Drug used in exoerythrocytic cycle of malaria

A

Primaquine

19
Q

Oral antibiotic of choice for moderate inflammatory acne

A

Minocycline

20
Q

Drug of choice for leprosy

A

Dapsone

21
Q

MOA of erythromycin

A

Inhibition of protein synthesis at the 50s subunit of ribosome

22
Q

Lactam that can be used in PCN allergic patients

A

Aztreonam

23
Q

SE of imipenem

A

Seizures

24
Q

Anti-viral with a dose limiting toxicity of pancreatitis

A

Didanosine

25
Q

Common side effect of hypnotic agents

A

Sedation

26
Q

Occurs when sedative hypnotics are used chronically or at high doses

A

Tolerance

27
Q

The most common type of drug interaction of sedative hypnotics with other depressant medications

A

Additive CNS depression

28
Q

Neurologic SE of benzodiazepines

A

Anterograde amnesia

29
Q

Main route of metabolism for benzodiazepines

A

Hepatic

30
Q

Benzodiazepine that undergo extrahepatic conjugation (which are useful in older or hepatically impaired)

A

Lorazepam, oxazepam, and temazepam

31
Q

MOA for benzodiazepines

A

increase the FREQUENCY of GABA-mediated chloride ion channel opening

32
Q

Partial opioid agonist, considered a strong analgesic, has a long duration of action and is resistant to naloxone reversal

A

Buprenorphine

33
Q

These agents are used as antitussive

A

Dextromethorphan, Codeine

34
Q

These agents are used as antidiarrheal

A

Diphenoxylate, Loperamide

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