Pharm 19

Question 2

SE of HMG COA reductase inhibitors

Answer 2

Rhabdomyolysis and Hepatotoxicity

Question 3

Cutaneous flush due to niacin can be reduced by pretreatment with

Answer 3

Aspirin

Question 4

Most common SE of fibrates

Answer 4

Nausea

Question 5

Fibrates are contraindicated in

Answer 5

Pregnancy

Question 6

Concurrent use of fibrates and statins increases risk of

Answer 6

Rhabdomyolysis

Question 7

Class of drugs that works by inhibiting absorption of intestinal cholesterol and can be given concurrently with the Statins

Answer 7

Ezetimibe (Zetia)

Question 8

MOA of NSAIDS

Answer 8

inhibit prostaglandin synthesis by inhibiting cyclo-oxygenase (cox)

Question 9

Difference between aspirin and other NSAIDS

Answer 9

Aspirin irreversibly inhibits cyclooxygenase

Question 10

Four main actions of NSAIDS

Answer 10

Anti-inflammatory, analgesia, antipyretic and antiplatelet activity

Question 11

Aspirin is contraindicated in children with viral infection

Answer 11

Potential for development of Reye’s syndrome

Question 12

SE of salicylates

Answer 12

Tinnitus, GI bleeding

Question 13

NSAID also available as an ophthalmic preparation

Answer 13

Diclofenac

Question 14

NSAID available orally, IM and ophthalmically

Answer 14

Ketoralac

Question 15

NSAID that is used for acute condition, such as pre-op anesthesia and has limited duration (<5 days) of use due to nephrotoxicity

Answer 15

Ketoralac

Question 16

Newer NSAIDs that selectively inhibit COX-2

Answer 16

Celecoxib and rofecoxib

Question 17

COX 2 inhibitors may have reduced risk of

Answer 17

Gastric ulcers and GI Bleeding

Question 18

COX 2 inhibitors should be used cautiously in pts with

Answer 18

Pre-existing cardiac or renal disease

Question 19

SE of acetaminophen

Answer 19

Hepatotoxicity

Question 20

MOA of gold salts

Answer 20

Alter activity of macrophages and suppress phagocytic activity of PMNs

Question 21

SE of gold salts

Answer 21

Dermatitis of the mouth aplastic anemia and agranulocytosis

Question 22

Causes bone marrow suppression

Answer 22

Methotrexate

Question 23

SE of penicillamine

Answer 23

Aplastic anemia and renal

Question 24

Interferes with activity of T-lymphocytes

Answer 24

Hydroxychloroquine

Question 25

Anti-malarial drug used in rheumatoid arthritis (RA)

Answer 25

Hydroxychloroquine

Question 26

SE of hydroxychloroquine

Answer 26

Retinal destruction and dermatitis

Question 27

MOA of Leflunomide (newer agent)

Answer 27

Inhibiting Dihydroorotate Dehydrogenase which leads to decreased pyrimidine synthesis

Question 28

Proteins that prevent action of tumor necrosis factor alpha (TNF-alpha)

Answer 28

Infliximab and etanercept

Question 29

Anti-rheumatic agent also used for ulcerative colitis

Answer 29

Sulfasalazine

Question 30

NSAID contraindicated in gout

Answer 30

Aspirin

Question 31

MOA of Colchicine (used in acute gout)

Answer 31

Selective inhibitor of microtubule assembly

Question 32

SE of colchicine

Answer 32

Kidney and liver toxicity

Question 33

Agent used to treat chronic gout by increasing uric acid excretion

Answer 33

Probenecid causes urinary excretion of uric acid and lowers serum urate concentrations