Pharm 12

Question 2

Enhances dopaminergic neurotransmission.

SE’s include CNS excitation, acute toxic psychosis and livedo reticularis

Answer 2

Amantadine

Question 3

MAO-B Inhibitor (which metabolizes dopamine), used adjunct to levodopa or as sole agent in newly diagnosed Parkinson pts

Answer 3

Selegiline

Question 4

Inhibitors of catechol-O-methyltransferase (COMT), used as adjuncts in Parkinson and cause acute hepatic failure (monitor LFT’s)

Answer 4

Entacapone and Tolcapone

Question 5

Agent decreases the excitatory actions of cholinergic neurons. May improve tremor and rigidity but have LITTLE effect on bradykinesia. Atropine-like side effects

Answer 5

Benztropine

Question 6

Agent effective in physiologic and essential tremor

Answer 6

Propranolol

Question 7

Agents used in Huntington’s Disease

Answer 7

Tetrabenazine (amine depleting drug), Haloperidol (antipsychotic)

Question 8

Agents used in Tourette’s

Answer 8

Haloperidol or pimozide

Question 9

Chelating agent used in Wilson’s disease

Answer 9

Penicillamine

Question 10

Extrapyramidal dysfunction is more common with these agents, which block this subtype of dopamine receptor

Answer 10

Older high potency typical antipsychotic agents (haloperidol, fluphenazine, pimozide)

Block D2 receptors

Question 11

Antipsychotics that reduce positive symptoms only

Answer 11

Older antipsychotics

Question 12

Newer atypical antipsychotics that also improve some of the negative symptoms and help acute agitation

Answer 12

Olanzapine and aripiprazole

Question 13

Newer atypical antipsychotic used for bipolar disorder, known to cause weight gain, and adversely affect diabetes

Answer 13

Olanzapine

Question 14

Agent more frequently associated with extrapyramidal side effects that can be treated with benzodiazepine, diphenhydramine or muscarinic blocker

Answer 14

Haloperidol

Question 15

Agents may exacerbate tardive dyskinesias (may be irreversible and there is no treatment)

Answer 15

Muscarinic blockers (atropine, scopolamine, ipratropium, benztropine, oxybuntin)

Question 16

Antipsychotic having the weakest autonomic effects

Answer 16

Haloperidol

Question 17

Only phenothiazine not exerting antiemetic effects.

Can cause visual impairment due to retinal deposits, and high doses have been associated with ventricular arrhythmias

Answer 17

Thioridazine

Question 18

Anti-psychotics available in depot preparation (injected, slow release)

Answer 18

Fluphenazine and haloperidol

Question 19

Reduced seizure threshold

Answer 19

Low-potency typical antipsychotics (chlorpromazine, thioridazine) and clozapine (atypical)

Question 20

Orthostatic hypotension and QT prolongation

Answer 20

Low potency (chlorpromazine, thioridazine) and risperidone (atypical)

Question 21

Increased risk of developing cataracts

Answer 21

Quetiapine

Question 22

Drug increases the renal clearance hence decreases levels of lithium

Answer 22

Theophylline

Question 23

Lithium is associated with this congenital defect

Answer 23

Cardiac anomalies and is contraindicated in pregnancy or lactation

Question 24

Example of three antidepressants that are indicated for obsessive compulsive disorder

Answer 24

Clomipramine, fluoxetine and fluvoxamine

Question 25

Neurotransmitters affected by the action of antidepressants

Answer 25

Norepinephrine and serotonin

Question 26

Usual time needed for full effect of antidepressant therapy

Answer 26

2 to 3 weeks

Question 27

Population group especially sensitive to side effects of antidepressants

Answer 27

Elderly patients

Question 28

All antidepressants have roughly the same efficacy in treating depression, agents are chosen based on these criterion

Answer 28

Side-effect profile and prior pt response

Question 29

Well-tolerated and are first-line antidepressants

Answer 29

SSRI’s, bupropion, and venlafaxine

Question 30

Most useful in patients with significant anxiety, phobic features, hypochondriasis, and resistant depression

Answer 30

Monamine oxidase inhibitors

Question 31

Condition will result from in combination of MAOI with tyramine containing foods (ex. wine, cheese, and pickled meats)

Answer 31

Hypertensive crisis