Which cells of the skin secrete antimicrobial peptides?
Which glands of the skin secrete antimicrobial peptides?
What are the antigen presenting cells of the skin?
What is the antibody mainly found on mucosal surfaces?
What complication of chemotherapy can cause GI infection and sepsis?
Which immune cells are mainly responsible for killing bacteria and fungi?
A deficiency in T lymphocytes makes you susceptible to infections by which organisms?
Which immune cells does HIV target?
CD4+ T cells
a) B cells mature into
b) monocytes mature into?
a) Plasma cells
Which biologic agent suppresses B cells?
HIV infection puts you at risk of which particular infection?
It also puts you at risk of ___ infections.
What problem with the spleen can cause infection?
What are some causes of hyposplenism?
Sickle cell, autoimmune stuff (check this)
___ patients are more likely to have opportunistic infections.
Do they show the same signs and symptoms as normal people?
What can be given to patients to reduce their risk of infection?
How does sepsis cause organ dysfunction?
Excessive, disordered immune response to infection
cytokines > vasodilation & leaky vessels > hypotension
What is the cardiovascular dysfunction seen in sepsis?
Why does it occur?
Widespread vasodilation due to toxins
Rx: fluids, inotropes, vasoconstrictors
What is the pulmonary dysfunction of sepsis?
Diffuse alveolar oedema (ARDS)
Leaky capillaries, lungs fill with fluid
What is the renal dysfunction of sepsis?
Acute kidney injury (AKI)
What is the hepatic dysfunction of sepsis?
Shock liver and jaundice due to hypoperfusion
What is the CNS dysfunction of sepsis?
Confusion / delerium due to cerebral hypoperfusion and toxins
What metabolic problem is seen in sepsis?
What causes it?
Widespread hypoperfusion > anaerobic respiration > acidosis due to lactic acid buildup
What is an organ dysfunction which can cause septic embolism?
Coagulopathy - increased clotting