6: Host infection interactions Flashcards Preview

CLASP: Sepsis 2017/18 > 6: Host infection interactions > Flashcards

Flashcards in 6: Host infection interactions Deck (23)
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1

Which cells of the skin secrete antimicrobial peptides?

Keratinocytes

2

Which glands of the skin secrete antimicrobial peptides?

Sebaceous glands

3

What are the antigen presenting cells of the skin?

Langerhans cells

4

What is the antibody mainly found on mucosal surfaces?

IgA

5

What complication of chemotherapy can cause GI infection and sepsis?

Mucositis

6

Which immune cells are mainly responsible for killing bacteria and fungi?

Phagocytes

macrophages, neutrophils

7

A deficiency in T lymphocytes makes you susceptible to infections by which organisms?

Viruses

Fungi

Parasites

intracellular organisms

8

Which immune cells does HIV target?

CD4T cells

9

What do

a) B cells mature into

b) monocytes mature into?

a) Plasma cells

b) Macrophages

10

Which biologic agent suppresses B cells?

Rituximab

11

HIV infection puts you at risk of which particular infection?

It also puts you at risk of ___ infections.

Strep. pneumoniae

Atypical infections

12

What problem with the spleen can cause infection?

Hyposplenism

13

What are some causes of hyposplenism?

Splenectomy

Sickle cell, autoimmune stuff (check this)

14

___ patients are more likely to have opportunistic infections.

Do they show the same signs and symptoms as normal people?

Immunocompromised

Noooooo

15

What can be given to patients to reduce their risk of infection?

Prophylaxis (rarely)

Vaccination

16

How does sepsis cause organ dysfunction?

Excessive, disordered immune response to infection

cytokines > vasodilation & leaky vessels > hypotension

17

What is the cardiovascular dysfunction seen in sepsis?

Why does it occur?

Hypotension

Widespread vasodilation due to toxins

Rx: fluids, inotropes, vasoconstrictors

18

What is the pulmonary dysfunction of sepsis?

Diffuse alveolar oedema (ARDS)

Leaky capillaries, lungs fill with fluid

Rx: oxygen

19

What is the renal dysfunction of sepsis?

Acute kidney injury (AKI)

Renal hypoperfusion

20

What is the hepatic dysfunction of sepsis?

Shock liver and jaundice due to hypoperfusion

21

What is the CNS dysfunction of sepsis?

Confusion / delerium due to cerebral hypoperfusion and toxins

22

What metabolic problem is seen in sepsis?

What causes it?

Lactic acidosis

Widespread hypoperfusion > anaerobic respiration > acidosis due to lactic acid buildup

23

What is an organ dysfunction which can cause septic embolism?

Coagulopathy - increased clotting