9: Antimicrobial stewardship

Question 1

Antibiotics are rapidly developing ___ to antibiotics.

Answer 1

resistance

Question 2

gentamicin:

alternative is aztreonam

step down is co-trimoxazole

Question 3

give septic patients IV drugs

exception: oral vanc in c diff, “topical” action in bowel

Question 4

bactericidal technically means that drug reduces bacterial population by 1000x

bacterostatic causes less than 1000x decline because it inhibits growth only

notable bacteriostatic drug is doxycycline

Question 5

beta lactamase resistant organisms:

cut out penicillin, cephalosporins and aztreonam

Question 6

iv antibiotics for biofilms (e.g endocarditis)