6.4 Investigating disseminated malignancy Flashcards Preview

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Flashcards in 6.4 Investigating disseminated malignancy Deck (13):
1

What are the routes of spread?

Lymphatic
Vascular
Seeding of body cavities and surfaces
Perineural

2

What is the tumour marker of adenocarcinoma?

CEA - carcinoembryonic antigen

3

What is the tumour marker of hepatocellular carcinoma and germ cell tumours?

AFP - alpha-fetoprotein

4

What is the tumour marker of epithelial ovarian cancer?

CA 125 - cancer antigen 125

5

What is the tumour marker of prostatic adenocarcinoma?

PSA - prostate specific antigen

6

What is the tumour marker of pancreatic cancer?

CA 19.9

7

What can you do from FNA, core and excision biopsy

FNA: cytology
Core and excision: histology

8

What stains can you do to classify tumours?

Cytokeratin - epithelial
Vimentin - mesenchymal
Leucocyte common antigen - lymphoid
S100 - melanocytes

9

What stains all epithelial cells?

AE1/AE3

10

CK7+

lung, breast, endometrium, ovary

11

CK20+

colorectal

12

CK7 and 20+

pancreatobiliary, urothelial

13

CK7 and 20-

prostate, liver