7.2 Tumours of CNS Flashcards Preview

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Flashcards in 7.2 Tumours of CNS Deck (9):
1

What is the function of astrocytes?

Provide metabolic support to the neurons and form the BBB - important for repair and scarring of nervous tissue

2

What is the function of oligodendrocytes and where are they found?

Produce the myelin sheath around the white matter
Found in the white matter

3

What is the function of Ependymal cells and where are they found?

Line the ventricles and produce CSF
Found in the ventricles

4

What is the function of microglia?

Macrophages of the CNS

5

What cells surround the cranial nerves?

Schwann cells

6

What is unique about primary tumours of the brain?

They do not metastasize

7

What are the symptoms of brain tumours?

Headache - intracranial pressure = BAD
Focal neurological deficits
Personality/mood chanes
Seizures
High intracranial pressure - headache worse in the morning, papilloedema
Premature puberty
Raised prolactin
Sudden death

8

What is the grading system for brain tumours?

AMEN
Atypia
Mitoses
Endothelial proliferation
Necrosis

Other: cellularity, molecular

9

What is the grade 1-4 WHO

I: low proliferation, possible cure following resection, grade stable
II: Recur as infiltrative, may be unstable
III: more aggressive recurrence with shorter time to demise - often need adjuvant chemo
IV: aggressive, high proliferation, rapid growth, usually fatal outcome