Urinary System Intro & glomerular filtration Flashcards

1
Q

What makes up the urinary system?

A

Bladder
Kidneys
Ureter
Urethra

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2
Q

What does the bladder do?

A

Store urine

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3
Q

What does the urethra do?

A

Convey urine to the outside world

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4
Q

What do the ureters do?

A

Transport urine from the kidney to the bladder

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5
Q

Where are the kidneys in the body?

A

Either side of the spine

Behind the caudal rib

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6
Q

What are the functions of the kidneys?

A

Regulate fluids and electrolytes
Excrete waste
Produce hormones

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7
Q

Blood enters and leaves the glomerulus via which vessels?

A

Enters via afferent arterioles

Leaves via efferent arteriole

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8
Q

What is the arterial/venous blood supply to and from the kidneys?

A
Renal artery
Segmental artery 
Inter-lobar artery
Arcuate artery 
Interlobular artery 
Interlobular vein
Arcuate vein
Inter-lobar vein
Segmental vein
Renal vein
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9
Q

Which blood vessels are found between the interlobular artery and vein?

A

Afferent arterioles
Glomerulus capillaries
Efferent arterioles
Peritubular capillaries

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10
Q

What is the difference between filtrate and urine?

A

Filtrate is in the nephron,

Filtrate becomes urine when it’s in the bladder

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11
Q

Why do cells and proteins not usually enter the kidney?

A

The membrane between the glomerulus and Bowman’s capsule is impermeable to most proteins. Cells are too large to pass through it

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12
Q

What happens in the proximal convoluted tubule?

A

Bulk reabsorption (unregulated)

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13
Q

What happens in the loop of Henle?

A

An osmotic gradient is set up

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14
Q

Describe the differences in permeability between the ascending and descending loop of Henle

A

Descending very permeable to water, little ion channels

Ascending very permeable to ions, not to water

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15
Q

Which ions are transported out of the descending limb? How are they transported?

A

Active transport

Na, K, Cl

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16
Q

What does the distal convoluted tubule do?

A

Controls reabsorption/secretion of water

and ions

17
Q

How long does it take the kidneys to filter out the entire volume of blood in the body?

A

25 minutes

18
Q

How much urine does a normal animal excrete?

A

1ml/kg/hour

19
Q

How are is the glomerulus adapted to filtration?

A

50X more permeable than normal capillaries

20
Q

Does Starling’s Law of capillaries apply to the glomerulus? What happens to the filtration pressure if oncotic pressure increases?

A

No - constantly filtering.

As oncotic pressure increases, filtration pressure increases

21
Q

The glomerulus does not have a normal capillary bed. What system does it use? What is different about this system?

A

Uses the portal system

There are two sets of capillaries before draining into the venule

22
Q

What 3 factors affect glomerular filtration rate?

A

Surface area of glomerular capillaries
Flow rate of glomerular capillaries
Hydrostatic pressure of glomerular capillaries

23
Q

Arterioles are able to control blood flow using what in their structure?

A

Smooth muscles

24
Q

How is glomerular filtrate rate maintained short term?

A

Myogenic response

Causes smooth muscle in afferent arterioles to vasoconstriction/dilate

25
Q

What effect does afferent arteriole vasoconstriction have on the GFR?

A

Decreases it

26
Q

What is the long term way of maintaining glomerular filtrate rate?

A

Tuboglomerular feedback

27
Q

How does tuboglomerular feedback work?

A

Macula densa cells in LOH detect increase in GFR
Causes a paracrine signal
Constricts arterioles and causes decrease in production of renin

28
Q

What is an autocrine response?

A

Cell releases a substance which binds on itself

29
Q

What is a paracrine response?

A

A hormone which has effect on the gland secreting it

30
Q

Which cells decrease the production of renin?

A

Juxtaglomerular cells

31
Q

What is renin

A

An enzyme which controls angiotensin levels

32
Q

What is angiotensin?

A

A hormone which controls blood pressure

33
Q

Which cells release renin?

A

Juxtaglomerular cells