7 - Derm - Psoriasis - Intro + Plaque psoriasis

Question 1

what is psoriasis

gender ratio, population prevalence

Answer 1

inflam and hyperproliferation of the skin
M=F
affects 2% population

Question 2

type 1 vs type 2

Answer 2

1 - commonly early onset - 16-22y - female onset earlier

2 - late onset - 55-60y

Question 3

6 steps of pathology

Answer 3

acanthosis
elongation of rete ridges
absent granular layer
neutrophilic and lymphohistiocytic infiltrate
polymorphonuclear abscesses
capillary dilatation

Question 4

genetic aetiology - % FHx

- % twin concordance

Answer 4

30% FHx

70% MZ twin concordance

Question 5

exacerbating factors - 7

Answer 5

infection (GAS)
drugs - lithium, BB, antimalarials
UV light
alcohol
smoking
stress
trauma

Question 6

plaque psoriasis - % of cases

-general appearance

Answer 6

90%

salmon pink, well demarcated plaques with silver scaling

Question 7

plaque psoriasis - features - where? what is the AUSPLITZ sign?

Answer 7

symmetrical
extensor surfaces knees elbows also back ears scalp
ausplitz - pinpoint bleeding on scraping of scale

Question 8

what may plaque psoriasis affect? what is also common?

Answer 8

affect nails - pitting, onycholysis (detachment), subungal hyperkeratosis

Koebner phenomenon common - linear config of plaques