1 - Paeds - Resp - Asthma - Mgmt

Question 1

what if not responding?

Answer 1

HDU/PICU. IVF salbutamol/aminophylline

Question 2

what if responding?

Answer 2

continue SABA 1-4h PRN, discharge when stable on 4h treatment, continue oral pred for 3d

Question 3

list 8 medications for asthma

Answer 3

B2 agonists
Anticholinergic bronchodilators
inhaled steroids
long acting B2 bronchodilators, methylxanthines, leukotriene inhibitors, oral steroids, anti-IgE injections

Question 4

B2 agonists- examples? cause? less effective in who?why?

Answer 4

salbutamol, terbutaline - bronchodilation, can be less effective in v young kids as they have fewer active beta receptors

Question 5

Anticholinergic bronchodilators - eg? how do they work?

Answer 5

ipratropium bromide

different receptor to BA - sympathetic system to achieve their affect

Question 6

inhaled steroids - eg? mechanism of action?

Answer 6

budesonide, beclametasone, fluticasone, mometasone

- preventers, prevent infl proteins creation - reduce any response caused by IgE or other chemical released

Question 7

Long acting B2 bronchodilators - examples?

Answer 7

salmeterol and formoterol - act on B2 receptors for longer than salbutamol

Question 8

Methylxanthines - eg? mech?

Answer 8

theophylline, relaxation of bronchiole SM

Question 9

Leukotriene inhibitors - example? when replaces LABA? mech?

Answer 9

montelukast
PO in <5s instead of LABA
-an antagonist , blocks LT action > reduces bronchoconstriction caused by it

Question 10

Oral steroids - eg? dif from inhaled?

Answer 10

pred

more potent and greater systemic effects + SE

Question 11

Anti-IgE injections- eg? what is it and how does it work

Answer 11

omalizumab - monoclonal antibody designed to target IgE and prevent an atopic reaction`