Dermatology

Question 1

Bullous Pemphigoid

Answer 1

IgG antibody against hemidesmosomes (epidermal basement membrane; antibodies are “bullow” the epidermis -Tense blisters containing eosinophils affect skin but spare oral mucosa. Immunofluorescence reveals linear pattern at epidermal-dermal junction D . Nikolsky sign ⊝

Question 2

Hemidesmosome

Answer 2

connects keratin in basal cells to underlying basement membrane. Autoantibodies bullous pemphigoid. (Hemidesmosomes are down “bullow”).

Question 3

Pemphigus Vulgaris

Answer 3

Autoimmune skin disorder with IgG antibody against desmoglein (component of desmosomes).

Flaccid intraepidermal bullae caused by acantholysis (keratinocytes in stratum spinosum are connected by desmosomes); oral mucosa also involved.

Immunofluorescence reveals antibodies around epidermal cells in a reticular (net-like) pattern B . Nikolsky sign ⊕

Question 4

Label this stupid figure

Answer 4

A. Zona Occuludens (tight junction)

B. Zonula Adherens (intermediate junction)

C. Desmosome

D. Gap Junction

E. Hemidesmasone