Which habit is altered in patients with IBD?
What is the main aim of IBD therapy?
What are the general therapy options for IBD?
Which lifestyle factor aggravates Crohn's disease?
Diet influences the gut ___ and therefore the symptoms of IBD patients.
Quitting smoking reduces the recurrence of which inflammatory bowel disease?
Drug therapy for IBD tends to have an anti____ effect.
Which class of drug was used exclusively for UC in the past?
Which classes of drugs are used in IBD?
5-ASAs are used in ___ ___ and reduce the risk of ___ ___.
What are the side effects of 5-ASAs e.g mesalazine?
Nephritis (check renal function regularly)
How can 5-ASAs be administered?
Higher doses of 5-ASAs tend to produce (greater / smaller) responses in UC patients.
5-ASAs are (oral/rectal/topical) therapies.
route of admin may be oral / enema but the drug coats the wall of the GI tract so it's topical
What is the first line therapy in Crohn's disease (and after 5-ASAs in UC)?
Corticosteroids have a systemic ___-___ effect.
What are some examples of oral steroids used in IBD?
Why are corticosteroids only used short-term in the treatment of IBD?
Steroid dependence / resistance
side effects: osteoporosis, see slides
What are some GI side effects of steroids?
What are steroid-sparing agents?
Medications used instead of corticosteroids in UC:
used after steroids (to avoid steroid dependence)
What drugs are used as a maintenance therapy in Crohn's disease?
Name some examples of immunosuppressors used in IBD therapy.
Which tests are done on someone who is taking azathioprine?
Azathioprine has a (fast / slow) onset of action.
What would be prescribed in the mean time?
What are some possible side effects of azathioprine therapy?
Which cells secrete TNFalpha?
during antigen presentation.
What is the function of TNFalpha?
drives recruitment of inflammatory immune cells
Which protein, involved in white cell adhesion in acute inflammation, is blocked by some IBD drugs?
Which drugs are used to inhibit the action of TNFalpha in IBD?
e.g infliximab, adalimumab
What respiratory disease may be reactivated by the action of anti TNFalpha drugs?