5: IBD clinical signs and symptoms Flashcards Preview

Gastrointestinal Week 5 2016/17 > 5: IBD clinical signs and symptoms > Flashcards

Flashcards in 5: IBD clinical signs and symptoms Deck (32)
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1

Normally, the gut acts as a ___ organ for the ___ immune system.

surveillance

mucosal

2

What are the two types of inflammatory bowel disease?

Crohn's disease

Ulcerative colitis

3

What symptoms tend to be seen in Crohn's disease?

Abdominal pain

Perianal disease

Watery diarrhoea

4

What symptoms tend to be seen in ulcerative colitis?

Bloody diarrhoea

5

What three factors are involved in the pathogenesis of IBD?

Genetics

Mucosal immune system

Environmental triggers

6

Which gene predisposes you to develop IBD?

NOD2

7

What does the NOD2 gene code for?

Proteins involved in bacterial recognition

8

Smoking (aggravates / protects against) Crohn's disease.

aggravates

9

Smoking (aggravates / protects against) ulcerative colitis.

protects against

10

Which class of drug aggravates colitis?

NSAIDs (ibuprofen, naproxen, diclofenac)

11

Which part of the GI tract does ulcerative colitis start in?

Where does it go after that?

Rectum

Proximally

12

If an acute flareup of UC doesn't clear up with drugs (e.g steroids), what is performed?

Colectomy

13

What are the main symptoms of ulcerative colitis?

Diarrhoea with blood

Increased bowel frequency

14

Lower abdominal pain in the left iliac fossa is characteristic of which disease?

Ulcerative colitis

15

What aspect of the past medical history is important in UC?

Antibiotics / NSAID use

Skin, eye, joint problems

16

What is the criteria for diagnosing severe UC?

>6 bloody stools within 24 hours

+ 1 or more of:

Fever

Tachycardia

Anaemia

17

What may be seen on the AXR of someone with UC?

Absence of stools

Mucosal oedema - thumb print sign

Toxic megacolon

18

What would be seen upon endoscopy of someone with UC?

Continous inflammation

Granular mucosa

Pseudopolyps

Absence of goblet cells

Crypt abscesses

19

Does UC affect the whole thickness of the gut?

No - mucosa only

20

What does ulcerative colitis increase your risk of?

Colorectal cancer

21

What are some extra-intestinal symptoms of UC?

Skin - rashes

Joint problems

Eye problems

Mouth ulcers

Oxalate renal stones

22

What gallbladder condition is associated with ulcerative colitis?

Primary sclerosing cholangitis

inflammation due to stricture in cystic duct

23

Which areas of the GI tract are affected by Crohn's disease?

Mouth to anus

24

What kind of lesions are seen in Crohn's disease?

How does this differ from UC?

Skip lesions

UC is continous, Crohn's skips bits of the GI tract

25

What kind of inflammation is seen in Crohn's disease?

Transmural

penetrates the whole gut wall

26

What is perianal disease associated with?

Crohn's disease

27

Give an example of a perianal disease associated with Crohn's.

Rectal abscesses

28

What is a complication of rectal abscesses seen in Crohn's disease?

Fistula formation

29

Why may someone with Crohn's disease become incontinent?

Damage to anal sphincters caused by abscesses

30

What pathology, causing bowel obstruction, is seen in Crohn's disease?

Strictures