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Gastrointestinal Week 5 2016/17 > 6: Pathology - IBD > Flashcards

Flashcards in 6: Pathology - IBD Deck (42)
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1

Although Crohn's disease affects anywhere from the mouth to the anus, where is it most commonly seen?

Terminal ileum

Colon

2

Which type of inflammation is seen in Crohn's disease?

Transmural inflammation

3

Who tends to be diagnosed with Crohn's disease?

Younger people (10-40 years old)

4

Crohn's disease tends to ___ over time.

relapse

5

___ mucosa is typical of Crohn's disease.

Cobblestone

6

Crohn's disease is (continuous / segmental) with ___ lesions.

segmental , skip

7

What are skip lesions?

Alternating areas of normal and inflamed tract

8

What is a granuloma?

Collection of macrophages surrounding a foreign particle

9

What aspect of the gut tissue is invaded/destroyed/inflamed in Crohn's disease?

Crypts

10

Crohn's granulomas are (caseating / non-caseating).

non-caseating

they DON'T look like cheese

11

What drugs are used to treat Crohn's disease?

Steroids

Immunosuppressants

12

If a Crohn's disease patient doesn't respond to treatment, what complication can occur?

Bowel obstruction

13

What rare structures may be seen in the gut wall of a Crohn's disease patient?

Pseudopolyps

14

In Crohn's disease, deep fissures form a ___ mucosa.

cobblestone

15

Crohn's disease inflammation is transmural. What does this mean?

Affects mucosa, lamina propria and submucosa

16

What is a complication of Crohn's disease?

Malabsorption

Short bowel syndrome due to resection

GALLSTONES

Fistulas

Perianal disease

17

Which gene is involved in the development of Crohn's disease?

NOD2

18

Smoking (exacerbates / alleviates) the symptoms of Crohn's.

exacerbates

19

Which immune cells are responsible for Crohn's disease?

T lymphocytes

Macrophages

too many pro-inflammatory cytokines

20

What is ulcerative colitis?

Chronic inflammation of the rectum and colon only

21

Does ulcerative colitis affect the whole thickness of the gut wall?

No - mucosa only

22

Who tends to be diagnosed with ulcerative colitis?

Tends to be young, but not children

and the elderly as well

23

Crohn's disease and ulcerative colitis are more common in (males / females).

males

24

Which part of the GI tract is nearly always involved in ulcerative colitis?

Rectum

25

Which parts of the GI tract is ulcerative colitis constricted to?

Rectum

Colon

26

What is the main symptom of UC?

Diarrhoea +/- blood and mucus

27

Like Crohn's disease, ulcerative colitis tends to come in ___.

waves

28

Ulcerative colitis, untreated, causes colon swelling and perforation. What is this called?

Toxic megacolon

quite uncommon now due to effectiveness of drugs - look out for characteristic features on AXR

29

Ulcerative colitis is a (continuous / segmental) disease.

continuous

30

What is the only example of a skip lesion seen in UC?

Caecal patch

for some reason