Although Crohn's disease affects anywhere from the mouth to the anus, where is it most commonly seen?
Which type of inflammation is seen in Crohn's disease?
Who tends to be diagnosed with Crohn's disease?
Younger people (10-40 years old)
Crohn's disease tends to ___ over time.
___ mucosa is typical of Crohn's disease.
Crohn's disease is (continuous / segmental) with ___ lesions.
segmental , skip
What are skip lesions?
Alternating areas of normal and inflamed tract
What is a granuloma?
Collection of macrophages surrounding a foreign particle
What aspect of the gut tissue is invaded/destroyed/inflamed in Crohn's disease?
Crohn's granulomas are (caseating / non-caseating).
they DON'T look like cheese
What drugs are used to treat Crohn's disease?
If a Crohn's disease patient doesn't respond to treatment, what complication can occur?
What rare structures may be seen in the gut wall of a Crohn's disease patient?
In Crohn's disease, deep fissures form a ___ mucosa.
Crohn's disease inflammation is transmural. What does this mean?
Affects mucosa, lamina propria and submucosa
What is a complication of Crohn's disease?
Short bowel syndrome due to resection
Which gene is involved in the development of Crohn's disease?
Smoking (exacerbates / alleviates) the symptoms of Crohn's.
Which immune cells are responsible for Crohn's disease?
too many pro-inflammatory cytokines
What is ulcerative colitis?
Chronic inflammation of the rectum and colon only
Does ulcerative colitis affect the whole thickness of the gut wall?
No - mucosa only
Who tends to be diagnosed with ulcerative colitis?
Tends to be young, but not children
and the elderly as well
Crohn's disease and ulcerative colitis are more common in (males / females).
Which part of the GI tract is nearly always involved in ulcerative colitis?
Which parts of the GI tract is ulcerative colitis constricted to?
What is the main symptom of UC?
Diarrhoea +/- blood and mucus
Like Crohn's disease, ulcerative colitis tends to come in ___.
Ulcerative colitis, untreated, causes colon swelling and perforation. What is this called?
quite uncommon now due to effectiveness of drugs - look out for characteristic features on AXR
Ulcerative colitis is a (continuous / segmental) disease.
What is the only example of a skip lesion seen in UC?
for some reason