Acute Phase Response

Question 1

Causes of inflammation

Answer 1

Trauma
Burns
Pancreatitis
Chronic inflammation due to autoimmune disorders

Question 2

Acute phase response to inflammation or infection

Answer 2

1. Traumas
2. Local response to create pro inflammatory cytokines
3. Liver/hepatocytes - modulation of protein synthesis
4. Acute phase response

Question 3

Sepsis is

Answer 3

Serious complication of an infection

Question 4

TNF a and IL1 does?

Answer 4

Causes fever
Release stress hormones

(norepinephrine, vasopressin, activation of the renin- angiotensin-aldosterone system).

Question 5

TNF a And IL1

Answer 5

Synthesis of IL 6 IL8 and interferon gamma

Question 6

Cytokines especially IL6

Answer 6

Stimulate release of acute phase reactants like CRP

Question 7

APP stands for

Answer 7

Acute phase prot ins

Question 8

APP used as

Answer 8

Ideal bio markers for inflammation

Question 9

Role of C reactive protein is

Answer 9

Remove toxic substances from damaged tissue

Question 10

C reactive protein synthesised where

Answer 10

Liver

Question 11

C reactive protein useful in

Answer 11

Assessing extent or activity of inflammation

Assessing response to treatment

Question 12

PCT kinetics provide important info on

Answer 12

Prognosis of sepsis patients