Intro to Hemostasis

Question 1

The second step of the extrinsic pathway, which needs to be in the presence of calcium, is Factor ____ binding to TF

Answer 1

VII

Question 2

Factor VIII boosts the production of ______ and is linked to IX

Answer 2

Xa

Question 3

Factor 7, 9, 10, and 2 are all dependant on _____ for Carboxylation to occur and reduce the glutamate to get a super negative charge

Answer 3

Vitamin K

Question 4

Endothelin is a powerful vaso_____, via PLC —> IP3—> and Calcium release

Answer 4

Constrictor

Question 5

The second step of the intrinsic pathway uses _____ and _____

Answer 5

HMWK and Factor XI

Question 6

vWF and Factor VIII are both made by ____ cells and megakaryocytes; NOT the liver. (These two actually are stuck together during circulation)

Answer 6

Endoethelial

Question 7

Factor _____ is the final one that makes covalent links across fibrin chains.

Answer 7

XIII

Question 8

_____ activates both Factor IX and Factor VIII in a positive loop.

Answer 8

Thrombin

Question 9

The first step of Extrinsic pathway is the exposure of _____ factor, which is normally not present in bloodstream

Answer 9

Tissue

Question 10

Serine Proteases regulate Coagulation _______

Answer 10

Forward

Question 11

Thrombomodulin, Protein C, and Protein S are all _____ Factors

Answer 11

Anti-Coagulant

Question 12

vWF links platelets together, but ALSO binds and travels with Factor _____ to promote its half-life

Answer 12

VIII

Question 13

_______ Mutation is the most common cause of thrombolytic disorder. It grants resistance to _____; so they’ll clot way too much and are at risk of DVT

Answer 13

Factor V Leiden, APC

Question 14

Warfarin blocks the function of Vitamin K from undergoing the chemical reaction ______

Answer 14

Reductase

Question 15

The Common Pathway starts with Factor ____ and then Factor ____ being activated to ultimately make Thrombin. Thrombin then chops Fibrinogen into Fibrin.

Answer 15

X, II (Prothrombin)

Question 16

Thrombin activates Factor V, which promotes the conversion of _____ into _____

Answer 16

Xa, II (Prothrombin)

Question 17

Out of the numerals, the two hemostatic factors that are Co-factors/Accelerants, are ____ and ____

Answer 17

V, VIII

Question 18

GPIIb-IIa is the main receptor for _____ that are upregulated when they’re activated and are linked with Fibrinogen

Answer 18

Platelets

Question 19

Thrombin and Thrombomodulin come together to activate Protein C, which then inhibits Factor _____ to put the brakes on the whole clotting cascase

Answer 19

Va

Question 20

Thrombomodulin is an _________ that binds to _____

Answer 20

Anti-Coagulant, Thrombin (II)

Question 21

The first step of the Intrinsic pathway uses Factor _____, overall problems with Intrinsic aren’t as serious.

Answer 21

XII

Question 22

Thrombopoietin is made by the _____, which is regulated by the platelet mass. TPO is degraded when there are a lot of platelets present. (Survival Driven)

Answer 22

Liver

Question 23

_____ Cleaves Fibrinogen into Fibrin

Answer 23

Thrombin (IIa)